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The role of shock waves on the biodamage induced by ion beam radiation
Cancer Nanotechnology ( IF 4.5 ) Pub Date : 2019-07-30 , DOI: 10.1186/s12645-019-0050-3
Pablo de Vera , Eugene Surdutovich , Andrey V. Solov’yov

Energetic ions irradiate the human body in different situations such as exposure to galactic cosmic rays and ion beam cancer therapy. Ions propagating through dense medium deposit energy on the nanometre scale, which cause large local doses in their tracks. This makes the mechanisms of the following biodamage different from that induced by photons. A distinctive feature of the scenario of radiation damage with ions is the potential hydrodynamic response of the liquid medium in the form of cylindrical shock waves around each ion's path. Recent studies of the predicted cylindrical shock waves produced by swift ions propagating in liquid water or biological environments along with their effects on biological media are discussed in this review. The reasons for the onset of cylindrical shock waves in the vicinity of the ion's path are analysed theoretically, following the hydrodynamic approach to their description. Then, the classical molecular dynamics simulations of ion-induced shock waves are presented and discussed. The effects of shock waves on the scenario of radiation damage at different values of linear energy transfer are discussed in detail including the most recently simulated chemical effects. A number of ideas of experiments, in which the shock waves could be discovered, are presented, and ideas for the future developments in this field are conveyed.

中文翻译:

冲击波对离子束辐射引起的生物损伤的作用

高能离子在不同情况下会辐射人体,例如暴露于银河宇宙射线和离子束癌症疗法。通过稠密介质传播的离子会在纳米级沉积能量,这会在其轨迹中引起较大的局部剂量。这使得随后的生物损伤机理不同于光子诱导的机理。离子对辐射造成损害的一个显着特征是,液体介质在每个离子路径周围呈圆柱形冲击波形式的潜在流体动力响应。在这篇综述中,我们讨论了由液态水或生物环境中传播的快速离子产生的预测圆柱形冲击波及其对生物介质的影响的最新研究。在离子附近产生圆柱形冲击波的原因 理论上将按照流体动力学方法对其路径进行描述。然后,提出并讨论了离子诱导冲击波的经典分子动力学模拟。详细讨论了冲击波在不同线性能量传输值下对辐射破坏情况的影响,包括最近模拟的化学作用。提出了许多可以发现冲击波的实验思想,并传达了该领域未来发展的思想。详细讨论了冲击波在不同线性能量传输值下对辐射破坏情况的影响,包括最近模拟的化学作用。提出了许多可以发现冲击波的实验思想,并传达了该领域未来发展的思想。详细讨论了冲击波在不同线性能量传输值下对辐射破坏情况的影响,包括最近模拟的化学作用。提出了许多可以发现冲击波的实验思想,并传达了该领域未来发展的思想。
更新日期:2019-07-30
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