ABSTRACT

Introduction: Periodontitis is an inflammatory dysbiotic disease. Among putative dysbiosis causes, transmission of Porphyromonas gingivalis between individuals of the same family remains unclear. The aim of this systematic review and meta-analysis is to assess the likelihood of shared detection of Porphyromonas gingivalis among cohabiting family members.

Methods: A literature search was conducted on different databases up to September 2018. Articles assessing the presence of P.gingivalis between members of the same family were screened. Only English literature was retrieved, whereas no limits were applied for bacterial sampling and detection methods.

Results: Overall, 26 articles published between 1993 and 2017 met the inclusion criteria. Of these, 18 articles were used for meta-analyses. Based on bacterial culture, the likelihood of an intra-familial transmission of P.gingivalis once a member of the family harbors the bacterium is estimated at 63.5% (n = 132 pairs of family members); this drops to 45% when pooling together culture and Polymerase-Chain-Reaction (n = 481 pairs), whereas it is estimated at 35.7% when genotyping is applied (n = 137 pairs).

Conclusion: Pooled results suggest that the likelihood of detecting P.gingivalis within within family members is moderately frequent. Personalized periodontal screening and prevention may consider intra-familial co-occurrence of P.gingivalis as feasible.

摘要

简介：牙周炎是一种炎症性的营养不良疾病。在推定的营养不良病因中，牙龈卟啉单胞菌在同一家族的个体之间的传播仍不清楚。该系统评价和荟萃分析的目的是评估在同居家庭成员中共同检测牙龈卟啉单胞菌的可能性。

方法：截至2018年9月，在不同的数据库上进行文献检索。筛选了评估同一家族成员之间牙龈卟啉单胞菌存在的文章。仅检索了英语文献，而对细菌采样和检测方法没有限制。

结果：总体而言，1993年至2017年发表的26篇文章符合纳入标准。其中有18篇文章用于荟萃分析。根据细菌培养，一旦家庭成员携带细菌，牙龈卟啉单胞菌在家族内传播的可能性估计为63.5％（n = 132对家庭成员）。当将培养物和聚合酶-链反应合并在一起时，这一比例下降到45％（n = 481对），而应用基因分型时估计为35.7％（n = 137对）。

结论：汇总结果表明，在家庭成员中检出牙龈卟啉单胞菌的可能性中等。个性化的牙周筛查和预防可能认为牙龈卟啉单胞菌在家族内同时存在是可行的。