Abstract

Study into the effect of vitamins A and E on total and differential leukocyte count, as well as morphometric parameters of lymphocytes in three carnivorous species—dark brown American mink (Neovison vison, Mustelidae), blue fox (Vulpes lagopus, Canidae), and silver fox (V. vulpes, Canidae)—was conducted. The highest white blood cells count (WBC count) and the largest surface area of lymphocytes and their nuclei in the peripheral blood were observed in mink, while the lowest indices were found in silver fox. Additional supplementation with vitamins A and E for 14 days had no effect on the WBC and differential leukocyte count, except for silver foxes receiving vitamin E, in which a decrease in relative eosinophils and monocytes content was observed. The action of vitamins was mainly manifested in changes in the lymphocytes’ morphometric parameters. The addition of vitamin A into the diet of mink and silver fox and vitamin E into only mink’s diet led to an increase in the surface area of lymphocytes and, in some cases, their nuclei, which was accompanied by a rise in the cytoplasm size in mink cells. In blue fox, on the contrary, both vitamins induced a decrease in the surface area of the lymphocytes and their nuclei. The observed changes may be associated with the immunomodulatory effects of vitamins A and E of the studied species of carnivorous mammals, while the found differences may be associated with features of the morphologic and functional organization of lymphocytes and the immune status.

中文翻译：

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维生素A和E对肉食哺乳动物（肉食动物）白细胞差异计数和淋巴细胞形态参数影响的比较研究。

摘要

研究维生素A和E对三种食肉物种（深褐色的美国水貂（Neovison vison，鼬科），蓝狐（Vulpes lagopus， Canidae）和银）的三种食肉物种的总白细胞和差异白细胞计数以及淋巴细胞形态参数的影响狐狸（V. vulpes，Canidae）-已进行。貂皮中白细胞计数最高（WBC计数），而外周血中淋巴细胞及其核的表面积最大，而银狐则最低。除了接受维生素E的银狐（其中相对嗜酸性粒细胞和单核细胞含量降低）外，额外补充14天的维生素A和E对WBC和白细胞差异无影响。维生素的作用主要表现在淋巴细胞形态参数的变化上。在貂和银狐的饮食中添加维生素A，仅在貂的饮食中添加维生素E，导致淋巴细胞表面积增加，在某些情况下还导致了它们的细胞核增加，随之而来的是细胞质的增加。貂细胞。在蓝狐中 相反，两种维生素都会引起淋巴细胞及其核表面积的减少。所观察到的变化可能与所研究的食肉哺乳动物物种的维生素A和E的免疫调节作用有关，而发现的差异可能与淋巴细胞的形态和功能组织特征以及免疫状态有关。