piR‐39980 promotes cell proliferation, migration, invasion and inhibits apoptosis via repression of SERPINB1 in human osteosarcoma,Biology of the Cell

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piR‐39980 promotes cell proliferation, migration, invasion and inhibits apoptosis via repression of SERPINB1 in human osteosarcoma
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-01-10 , DOI: 10.1111/boc.201900063
Basudeb Das ₁ , Neha Jain ₁ , Bibekanand Mallick ₁

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Piwi‐interacting RNAs (piRNAs) are a novel class of ∼23–36 nts long endogenous small non‐coding RNAs, earlier known to maintain germline genome integrity during development by regulating transposable elements. Recently, piRNAs are known to regulate cell proliferation, apoptosis and metastasis in different cancer cells. However, piRNAs have not yet been reported in human osteosarcoma (OS), a highly metastatic aggressive bone tumour among adolescents. Therefore, our current study aimed to decrypt the potential role of a piRNA, piR‐39980 in osteosarcoma, which was earlier reported by us in fibrosarcoma, neuroblastoma and epithelial ovarian cancer.

中文翻译：

piR-39980通过抑制人骨肉瘤中的SERPINB1促进细胞增殖、迁移、侵袭并抑制细胞凋亡

Piwi-interacting RNAs (piRNAs) 是一类新的~23-36 nts 长的内源性小非编码 RNA，早先已知通过调节转座因子在发育过程中保持种系基因组的完整性。最近，已知 piRNA 可调节不同癌细胞的细胞增殖、凋亡和转移。然而，尚未在人类骨肉瘤 (OS) 中报道 piRNA，这是一种在青少年中具有高度转移性的侵袭性骨肿瘤。因此，我们目前的研究旨在揭示 piRNA piR-39980 在骨肉瘤中的潜在作用，我们早先在纤维肉瘤、神经母细胞瘤和上皮性卵巢癌中报道了这一点。

更新日期：2020-01-10

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