The ability of 3-hydroxy-6-methyl-2-ethylpyridine 2-nitroxysuccinate (I) to generate nitrite ions (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{NO}}_{2}^{ - }$$\end{document}) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. Compound I has been found to release \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{NO}}_{2}^{ - }$$\end{document} and NO more efficiently than Nicorandil. The accumulation rate of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{NO}}_{2}^{ - }$$\end{document} in the system of Cys with I is by a factor of 1.5 higher than that with Nitroglycerin. It has been shown that, in contrast to Nitroglycerin, compound I is not reduced by Hb.

中文翻译：

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3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate 和参考药物在模型 NO 生成系统中的反应性

3-hydroxy-6-methyl-2-ethylpyridine 2-nitroxysuccinate (I) 产生亚硝酸根离子的能力 (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage {amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{NO}}_{2}^{ - } $$\end{document}) 和一氧化氮 (NO) 在具有半胱氨酸 (Cys) 和脱氧血红蛋白 (Hb) 的模型系统中进行了研究。已发现化合物 I 可释放 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{NO}}_{2}^{ - }$$\end{document} 并没有比尼可地尔更有效。\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{ 的累积率\oddsidemargin}{-69pt} \begin{document}$${\text{NO}}_{2}^{ - }$$\end{document} 在具有 I 的 Cys 系统中高出 1.5 倍与硝酸甘油相比。已经表明，与硝酸甘油相比，化合物 I 不会被 Hb 还原。