A three-dimensional electrochemical system was employed as an advanced treatment technology for treatment of tetracycline-containing wastewater. An initial tetracycline concentration of 20.17–100.23 mg/L, pH range of 2.43–9.18, and current density of 1.03–15.72 mA/cm² were implemented for the optimization and modeling of the process within the framework of a three-factor, five-level Box–Wilson central composite design-based response surface methodology and least squares support vector machine. The results of statistics corroborated that three main effective factors and reactor performance were very well described by the second-order polynomial equation (coefficient of determination = 0.94, mean square error = 0.0042, root mean square error = 0.065, average absolute deviation = 2.51, and mean absolute error = 0.037). Under the optimal conditions introduced by the desirability function approach, 90.42 (± 2.3)%, 49.91 ± (8.4)% and 28.80 ± (16.70)% of tetracycline, chemical oxygen demand, and total organic carbon could be removed using the three-dimensional electrochemical process from wastewater. The findings of this study demonstrated that the three-dimensional electrochemical system was as an effective, simple, and economic process compared to other electrochemical systems that have been recently used for antibiotics removal and could be considered as a promising technology for further investigations.

三维电化学系统被用作处理四环素废水的先进处理技术。初始四环素浓度为20.17–100.23 mg / L，pH范围为2.43–9.18，电流密度为1.03–15.72 mA / cm ²在三因素，五级Box-Wilson基于中央复合设计的响应面方法和最小二乘支持向量机的框架内，对过程进行了优化和建模。统计结果证实，通过二阶多项式方程可以很好地描述三个主要影响因素和反应堆性能（测定系数= 0.94，均方误差= 0.0042，均方根误差= 0.065，平均绝对偏差= 2.51，和平均绝对误差= 0.037）。在期望函数方法引入的最佳条件下，可以使用三维方法去除四环素的90.42（±2.3）％，49.91±（8.4）％和28.80±（16.70）％，化学需氧量和总有机碳废水的电化学过程。