The fibrinogen receptor is an integrin on the platelet surface and is shaped from two types of glycoprotein (GP) subunits, GPIIb and GPIIIa. Membrane glycoprotein IIb/IIIa plays an important role in platelet function. The gene encoding the glycoprotein IIIa shows a common polymorphism, PLA2 that increases the binding of the receptor to fibrinogen and enhances the platelet aggregation. The clinical impact of PLA2 polymorphism has been studied in some diseases, but the definition of its exact role on venous thromboembolism complications has been challenging. The present systematic review aimed to clarify the association of PLA2 polymorphism and venous thromboembolism. In this study, Electronic databases including PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched. All the assessed studies focused on the relationship between PLA2 polymorphism and venous thromboembolism. Five studies were eligible for systematic review. One study revealed a significant correlation between PLA2 polymorphism and venous thromboembolism. PLA2 polymorphism was associated with deep vein thrombosis in one study and pulmonary thromboembolism in another one. The published data supported the hypothesis that having the PLA2 polymorphism of GPIIIa may be a risk factor for venous thromboembolism, but the association cannot be concluded; it needs more clinical investigation.

中文翻译：

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纤维蛋白原受体（糖蛋白 IIb）多态性与静脉血栓栓塞风险之间的关联：系统评价

纤维蛋白原受体是血小板表面的整合素，由两种类型的糖蛋白 (GP) 亚基 GPIIb 和 GPIIIa 形成。膜糖蛋白 IIb/IIIa 在血小板功能中起重要作用。编码糖蛋白 IIIa 的基因显示出一种常见的多态性，即 PLA2，它增加了受体与纤维蛋白原的结合并增强了血小板聚集。PLA2 多态性的临床影响已在一些疾病中得到研究，但其对静脉血栓栓塞并发症的确切作用的定义一直具有挑战性。本系统评价旨在阐明 PLA2 多态性与静脉血栓栓塞的关联。在本研究中，检索了包括 PubMed、Embase、Scopus、Web of Science 和 Cochrane Library 在内的电子数据库。所有评估的研究都集中在 PLA2 多态性与静脉血栓栓塞之间的关系上。五项研究符合系统评价的条件。一项研究揭示了 PLA2 多态性与静脉血栓栓塞之间的显着相关性。PLA2 多态性在一项研究中与深静脉血栓形成有关，在另一项研究中与肺血栓栓塞有关。已发表的数据支持GPIIIa的PLA2多态性可能是静脉血栓栓塞的危险因素的假设，但无法得出相关性结论；它需要更多的临床调查。PLA2 多态性在一项研究中与深静脉血栓形成有关，在另一项研究中与肺血栓栓塞有关。已发表的数据支持GPIIIa的PLA2多态性可能是静脉血栓栓塞的危险因素的假设，但无法得出相关性结论；它需要更多的临床调查。PLA2 多态性在一项研究中与深静脉血栓形成有关，在另一项研究中与肺血栓栓塞有关。已发表的数据支持GPIIIa的PLA2多态性可能是静脉血栓栓塞的危险因素的假设，但无法得出相关性结论；它需要更多的临床调查。