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Adverse Childhood Experiences are Associated with High-Intensity Binge Drinking Behavior in Adulthood and Mediated by Psychiatric Disorders
Alcohol and Alcoholism ( IF 2.1 ) Pub Date : 2020-01-02 , DOI: 10.1093/alcalc/agz098
Jeesun Jung 1 , Daniel B Rosoff 1 , Christine Muench 1 , Audrey Luo 1 , Martha Longley 1 , Jisoo Lee 1 , Katrin Charlet 1 , Falk W Lohoff 1
Affiliation  

Aim
High-intensity binge drinking (HIBD), defined as two or more times the gender-specific binge threshold, is rapidly increasing in the USA; however, the underlying contributing factors are poorly understood. This study investigated the relationship of adverse childhood experiences (ACEs) and HIBD.
Methods
Two independent, cross-sectional samples were analysed: (a) past 12-month drinkers in the National Epidemiological Survey on Alcohol and Related Conditions-III (NESARC-III; n = 25,552) and (b) the National Institute on Alcohol Abuse and Alcoholism (NIAAA) clinical sample (n = 1303). Multinomial logistic regressions were utilized to estimate adjusted odds ratios (AORs) of ACEs on HIBD. Mediation analysis was performed to examine the relationship between the past 12-month psychiatric disorders, ACEs, and HIBD.
Results
In the NESARC-III sample, prevalence of ACEs increased across all binge levels with the highest prevalence in extreme HIBD; ACEs were associated with higher odds for HIBD (level II, odds ratio (OR) = 1.2–1.4; P = 0.03–0.001; level III, OR = 1.3–1.9; P < 0.001). Prevalence of DSM-5 diagnoses also increased across all binge levels. Substance use disorders (SUD), mood, personality and post-traumatic stress disorders (PTSD) conferred the highest odds with extreme HIBD (SUD: OR = 21.32; mood: 1.73; personality: 2.84; PTSD: 1.97; all Ps < 0.001). Mediation analyses showed that the association between ACEs and HIBD was fully mediated through SUD (proportion mediated: 70–90%) and partially through other psychiatric disorders (20–80%). In the NIAAA sample, ACEs were 2–5 times more prevalent in extreme HIBD with higher odds (ORs = 3–8, P < 0.001) compared with non-bingers.
Conclusion
ACEs were associated with significantly increased odds of HIBD and the relationship may be mediated by psychiatric disorders.


中文翻译:


不良的童年经历与成年后的高强度酗酒行为有关,并由精神疾病介导


 目的

高强度暴饮 (HIBD) 定义为特定性别暴饮阈值的两倍或以上,在美国正在迅速增加;然而,人们对潜在的影响因素知之甚少。本研究调查了不良童年经历 (ACE) 与 HIBD 的关系。
 方法

对两个独立的横断面样本进行了分析:(a) 国家酒精和相关病症流行病学调查 III (NESARC-III;n = 25,552) 中过去 12 个月的饮酒者和 (b) 国家酒精滥用研究所和酒精中毒 (NIAAA) 临床样本 (n = 1303)。利用多项逻辑回归来估计 HIBD ACE 的调整优势比 (AOR)。进行中介分析以检查过去 12 个月的精神疾病、ACE 和 HIBD 之间的关系。
 结果

在 NESARC-III 样本中,所有暴饮水平中 ACE 的患病率均有所增加,其中极端 HIBD 的患病率最高; ACE 与 HIBD 的较高几率相关(II 级,比值比 (OR) = 1.2–1.4;P = 0.03–0.001;III 级,OR = 1.3–1.9;P < 0.001)。所有暴食水平的 DSM-5 诊断患病率也有所增加。药物使用障碍 (SUD)、情绪、人格和创伤后应激障碍 (PTSD) 导致极端 HIBD 的几率最高(SUD:OR = 21.32;情绪:1.73;性格:2.84;PTSD:1.97;所有 Ps < 0.001) 。中介分析表明,ACE 和 HIBD 之间的关联完全通过 SUD 介导(介导比例:70-90%),部分通过其他精神疾病介导(20-80%)。在 NIAAA 样本中,与非酗酒者相比,极端 HIBD 中 ACE 的发生率高出 2-5 倍,且几率更高(OR = 3-8,P < 0.001)。
 结论

ACE 与 HIBD 发病率显着增加相关,这种关系可能是由精神疾病介导的。
更新日期:2020-04-17
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