This meta-analysis was conducted to assess the consistency and strength of the relationship between polymorphism of IL-2 -330T/G and susceptibility to pulmonary tuberculosis (TB). PubMed, Web of Knowledge and CNKI were searched to find eligible studies about the relationship between IL-2 -330T/G polymorphism and susceptibility to pulmonary TB. A total of eight studies comprising 971 cases and 1519 controls were grouped together for the purpose of elucidating the relationship between polymorphism of IL-2 -330T/G and pulmonary TB susceptibility. The allele model (G vs. T: odds ratio (OR) = 1.34; 95% confidence interval (CI) 1.05–1.71, P_het = 0.001) and the recessive model (GG+GT vs. TT: OR = 1.60; 95% CI 1.08–2.38, P_het = 0.0001) showed an increased risk of development of pulmonary TB. However, the homozygous model (GG vs. TT: OR = 1.74; 95% CI 0.98–3.09, P_het = 0.0005) and the dominant model (GG vs. TT + TG: OR = 1.30; 95% CI = 0.80-2.14, P_het = 0.001) failed to show an increased incidence of pulmonary TB. When analysis was stratified by ethnicity, no obvious associations were identified in the Caucasian subgroup under all four genetic models. Additionally, heterogeneity disappeared in the analysis of Caucasian subgroup. Our combined data suggested that there was no association between IL-2 -330T/G polymorphism and pulmonary TB among Caucasians.

进行这项荟萃分析，以评估IL-2 -330T / G多态性与肺结核（TB）易感性之间关系的一致性和强度。搜索PubMed，Web of Knowledge和CNKI，以寻找有关IL-2 -330T / G多态性与肺结核易感性之间关系的合格研究。为了阐明IL-2 -330T / G基因多态性与肺结核易感性之间的关系，总共对包括971例病例和1519例对照的八项研究进行了分组。等位基因模型（G与T：比值比（OR）= 1.34； 95％置信区间（CI）1.05-1.71，P _het  = 0.001）和隐性模型（GG + GT与TT：OR = 1.60； 95） ％CI 1.08–2.38，P _het = 0.0001）显示患肺结核的风险增加。然而，纯合模型（GG vs. TT：OR = 1.74； 95％CI 0.98–3.09，P _het  = 0.0005）和显性模型（GG vs. TT + TG：OR = 1.30； 95％CI = 0.80-2.14 ，P _het  = 0.001）未能显示出肺结核的增加。当按种族对分析进行分层时，在所有四个遗传模型下的白种人亚组中均未发现明显的关联。此外，在白种人分组中，异质性消失了。我们的综合数据表明，IL-2 -330T / G多态性与白种人之间无关联。