Tissue engineering is widely accepted as an effective way to treat critical size bone defect. However, fabricating the scaffold functioning as an extracellular matrix and liable for cell proliferation with excellent material and design parameter to match closely with the natural bone property is still a challenge. The present paper focuses on finite element analysis (FEA) for getting the optimized architecture design by keeping extrusion-based 3D printing in mind. Predicting and optimizing the property of scaffold through FEA was performed on a 3D printing process such as selective laser sintering (SLS) and stereolithography (SLA), but for extrusion-based 3D printing, such literature is very few. In the present paper, the various geometrical design parameters for extrusion-based 3D printed scaffold were studied. A total of 36 scaffolds were analyzed by FEA to predict the porosity and Young’s modulus of the composite material. Based on the FEA result, the best scaffold with the optimum mechanical property was suggested. This article significance goes far beyond the specific objective to which it is dedicated. It shows a guideway for scaffold architecture design process matching the natural human tissue of interest.

中文翻译：

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用于骨组织工程的 3D 打印生物陶瓷支架结构设计的几何建模和有限元仿真

组织工程被广泛接受为治疗临界尺寸骨缺损的有效方法。然而，以优异的材料和设计参数制造具有细胞外基质功能并易于细胞增殖的支架以与天然骨特性紧密匹配仍然是一个挑战。本论文侧重于有限元分析 (FEA)，以通过牢记基于挤压的 3D 打印来获得优化的架构设计。通过有限元分析预测和优化支架的性能是在选择性激光烧结 (SLS) 和立体光刻 (SLA) 等 3D 打印工艺上进行的，但对于基于挤出的 3D 打印，此类文献很少。在本文中，研究了基于挤压的 3D 打印支架的各种几何设计参数。通过 FEA 分析了总共 36 个支架，以预测复合材料的孔隙率和杨氏模量。根据有限元分析结果，建议具有最佳力学性能的最佳支架。这篇文章的意义远远超出了它所致力于的特定目标。它显示了与感兴趣的自然人体组织相匹配的脚手架架构设计过程的指南。