Heart failure (HF) is a syndrome caused by structural and/or functional cardiac abnormalities, resulting in a reduced cardiac output and/or elevated intracardiac pressures. Several studies reported a crucial role of immune activation and inflammation in the chronic heart failure (HF) pathogenesis, suggesting that pro-inflammatory and anti-inflammatory mediators could be predictive markers of the HF development and/or progression. Human Leukocyte Antigen-G (HLA-G), a tolerogenic and anti-inflammatory class I non-classical major histocompatibility complex molecule, was reported to be upregulated in patients diagnosed with HF, suggesting a tentative to regulate the inflammatory condition. We evaluated soluble (s)HLA-G plasmatic levels in patients with stable chronic heart failure at baseline visit and after 6 and 12 months. The 14 bp Insertion/Deletion polymorphisms of the HLA-G gene was also analyzed. We showed that in HF subjects, sHLA-G levels were higher in NYHA class II and III subjects (mild-severe symptoms) (6.11 ± 1.15 ng/ml; 8.25 ± 2.27 ng/ml, respectively) in comparison with NYHA class I subjects (no symptoms) (2.35 ± 0.43 ng/ml) (I vs II: p = 0.0156; I vs III: p = 0.0122). Moreover, the exposure to chemicals seems to affect sHLA-G levels, with higher sHLA-G levels in exposed patients (3.36 ± 5.12 ng/ml) in comparison with unexposed subjects (2.01 ± 2.84 ng/ml). The HLA-G 3′UTR 14 bp INS/DEL polymorphism correlated with sHLA-G, with the 14 bp INS/INS genotype associated with higher sHLA-G levels during the 12 months follow-up in unexposed subjects (p = 0.008). In conclusion, these results support a correlation between sHLA-G levels, genetics and HF disease in presence of work chemical exposition.

心力衰竭（HF）是由结构和/或功能性心脏异常导致的综合征，导致心输出量降低和/或心内压升高。几项研究报告了免疫激活和炎症在慢性心力衰竭（HF）发病机理中的关键作用，表明促炎和抗炎介质可能是HF发生和/或发展的预测标志。据报道，人类白细胞抗原-G（HLA-G）是一种致耐受性和抗炎性的I类非经典主要组织相容性复合物分子，在诊断为HF的患者中表达上调，提示尝试调节炎症性疾病。我们在基线访视时以及6和12个月后评估了稳定的慢性心力衰竭患者的可溶性（s）HLA-G血浆水平。还分析了HLA-G基因的14 bp插入/缺失多态性。我们显示在HF受试者中，NYHA II类和III类受试者（轻度严重症状）的sHLA-G水平高于NYHA I类受试者（分别为6.11±1.15 ng / ml； 8.25±2.27 ng / ml） （无症状）（2.35±0.43 ng / ml）（I vs II：p = 0.0156； I vs III：p = 0.0122）。此外，接触化学药品似乎会影响sHLA-G水平，与未接触受试者（2.01±2.84 ng / ml）相比，接触患者的sHLA-G水平更高（3.36±5.12 ng / ml）。HLA-G 3'UTR 14 bp INS / DEL多态性与sHLA-G相关，未接触受试者的12个月随访中14 bp INS / INS基因型与更高的sHLA-G水平相关（p = 0.008）。总之，这些结果支持sHLA-G水平之间的相关性，