Chlorine‐based disinfectants protect pool water from pathogen contamination but produce potentially harmful halogenated disinfection by‐products (DBPs). This study characterized the bioaccumulation and elimination of exhaled DBPs post‐swimming and investigated changes in exhaled breath profiles associated with chlorinated pool exposure. Nineteen participants provided alveolar‐enriched breath samples prior to and 5, 90, 300, 510, and 600 minutes post‐swimming. Known DBPs associated with chlorinated water were quantitated by thermal desorption‐gas chromatography‐mass spectrometry. Two distinct exhaled DBP elimination profiles were observed. Most participants (84%) reported peak concentrations immediately post‐swimming that reduced exponentially. A sub‐group exhibited a previously unobserved and delayed washout profile with peak levels at 90 minutes post‐exposure. Metabolomic investigations tentatively identified two candidate biomarkers associated with swimming pool exposure, demonstrating an upregulation in the hours after exposure. These data demonstrated a hitherto undescribed exhaled DBP elimination profile in a small number of participants which contrasts previous findings of uniform accumulation and exponential elimination. This sub‐group which exhibited delayed peak‐exhaled concentrations suggests the uptake, processing, and immediate elimination of DBPs are not ubiquitous across individuals as previously understood. Additionally, non‐targeted metabolomics highlighted extended buildup of compounds tentatively associated with swimming in a chlorinated pool environment that may indicate airway responses to DBP exposure.

中文翻译：

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消毒副产物的替代呼气消除曲线的证据，以及在氯化池环境中游泳时呼吸道反应的潜在标志物。

含氯消毒剂可保护游泳池水免受病原体污染，但会产生潜在有害的卤化消毒副产物（DBP）。这项研究描述了游泳后呼出的DBP的生物蓄积和消除，并调查了与氯化物池暴露相关的呼出呼吸特征的变化。在游泳之前以及游泳后5、90、300、510和600分钟，有19名参与者提供了富含肺泡的呼吸样本。通过热脱附-气相色谱-质谱法对与氯化水有关的已知DBP进行定量。观察到两个不同的呼出DBP消除曲线。大多数参与者（84％）报告游泳后立即达到峰值浓度，并呈指数下降。一个亚组表现出以前未被观察到的和延迟的洗脱曲线，在暴露后90分钟达到峰值。代谢组学研究初步确定了两个与游泳池暴露相关的候选生物标志物，表明暴露后数小时内表达上调。这些数据证明了少数参与者迄今尚未描述的呼出气DBP消除特征，这与以前的均匀积累和指数消除的发现形成了对比。如前所述，该亚组表现出峰值呼气浓度延迟，这表明DBP的吸收，加工和立即消除在各个个体中并不普遍。另外，