An increase in the prevalence of Inflammatory Bowel Diseases (IBD) as a multifactorial intestinal chronic inflammation as well as the absence of a certain cure, has created an innovative era in the management of IBD by molecule/pathway-based anti-inflammatory approaches. There are credible documentations that demonstrate Mitogen-Activated Protein Kinases (MAPK) acts as IBD regulator. Upon the activation of MAPK signalling pathway, the transcription and expression of various encoding inflammatory molecules implicated in IBD are altered, thereby exacerbating the inflammation development. The current pharmacological management of IBD, including drug and biological therapies are expensive, possess temporary relief and some adverse effects. In this context, a variety of dietary fruits or medicinal herbs have received worldwide attention versus the development of IBD. Infact, natural ingredients, such as Flavaglines, Fisetin, Myricitrin, Cardamonin, Curcumin, Octacosanol and Mangiferin possess protective and therapeutic effects against IBD via modulation of different segments of MAPK signaling pathway. This review paper calls attention to the role of MAPK signaling triggered by natural products in the prevention and treatment of IBD.

作为多因素肠道慢性炎症的炎症性肠病（IBD）的患病率增加以及缺乏某种治愈方法，已经通过基于分子/途径的抗炎方法在IBD的治疗方面开创了一个创新时代。有可靠的文档证明了丝裂原激活的蛋白激酶（MAPK）作为IBD调节剂。在激活MAPK信号传导途径后，涉及IBD的各种编码炎症分子的转录和表达被改变，从而加剧了炎症的发展。当前IBD的药理学管理包括药物和生物疗法昂贵，具有暂时的缓解作用和一些副作用。在这种情况下，与IBD的发展相比，各种各样的饮食水果或草药已经受到了全世界的关注。实际上，天然成分，例如Flavaglines，Fisetin，Myricitrin，Cardamonin，姜黄素，Octacosanol和Mangiferin通过调节MAPK信号传导途径的不同部分而具有针对IBD的保护和治疗作用。这篇综述文章提请人们注意天然产物触发的MAPK信号传导在IBD预防和治疗中的作用。