Abstract

Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patients with radiculomyelopathy. The first patient was a 73-year old man treated with parotidectomy and irradiation for lymphoma of the neck. Following a Yersinia infection, he developed a radiculomyelopathy in C3/C4 and could not elevate his arms. The second patient was a 34-year old woman who was admitted 8 months after allogeneic hematopoietic stem cell transplantation due to hemolysis, impaired sensorium below arcus, and difficulty in ambulation. Following intravenous infusion of DSCs (1 × 10⁶/kg/infusion), the first patient could elevate his arms to the facial level. He experienced recurrent paralysis after 6 months, and the efficacy of four additional DSC infusions, at subsequent occasions, were limited and transient. The second patient was treated with two doses of DSCs (1 × 10⁶/kg/infusion). After cell infusion, she was able to stand on one leg, sensation in the belly normalized, and she was discharged. These two cases suggest that DSCs may be useful in the treatment of neuroinflammatory disorders.

中文翻译：

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两名胎盘来源的蜕膜基质细胞治疗神经根病。

摘要

间充质基质细胞可逆转急性炎症性疾病。胎盘对胎儿-母亲的耐受性很重要。我们已经使用胎盘来源的蜕膜基质细胞（DSC）来治疗移植物抗宿主疾病，并发现了免疫调节和抗炎作用。我们在这里报告了DSCs在两名患有神经脊髓病的患者中的使用。第一名患者是一名73岁的男子，接受腮腺切除术并接受了颈部淋巴瘤放射治疗。继耶尔森氏菌感染，他开发了C3 / C4一个radiculomyelopathy并不能提高他的手臂。第二例患者是一名34岁的女性，由于溶血，弓形下方的感觉层受损以及移动困难，在异体造血干细胞移植后8个月入院。静脉输注DSC（1×10⁶ / kg /输液），第一位患者可以将手臂抬高到面部。他在六个月后经历了复发性麻痹，在随后的情况下，四次额外的DSC输注的疗效有限且短暂。第二例患者接受了两剂DSC（1×10 ⁶ / kg /输液）。输注细胞后，她能够站立在一条腿上，腹部的感觉恢复正常，并且她出院了。这两个案例表明，DSC可能在神经炎性疾病的治疗中有用。