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Rapid and efficient one-pot synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives through the Hantzsch four component condensation by zinc oxide
Journal of the Iranian Chemical Society ( IF 2.4 ) Pub Date : 2009 , DOI: 10.1007/bf03245840
F. Matloubi Moghaddam , H. Saeidian , Z. Mirjafary , A. Sadeghi

A one-pot four-component reaction of aldehydes, ethyl acetoacetate/5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate in the presence of 10 mol% of ZnO as a heterogeneous catalyst for the synthesis of corresponding 1,4- dihydropyridine and polyhydroquinoline derivatives via the Hantzsch condensation is described. The present methodology offers several advantages such as simple procedure, excellent yields, and short reaction time.

中文翻译:

氧化锌通过Hantzsch四组分缩合反应快速高效地一锅合成1,4-二氢吡啶和聚氢喹啉衍生物

乙醛,乙酰乙酸乙酯/ 5,5-二甲基-1,3-环己烷二酮,乙酰乙酸乙酯和乙酸铵的单锅四组分反应,在10摩尔%ZnO作为非均相催化剂的存在下,用于合成相应的1描述了通过Hantzsch缩合的1,4-二氢吡啶和聚氢喹啉衍生物。本方法提供了许多优点,例如操作简单,产率高和反应时间短。
更新日期:2020-09-12
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