Calcium aluminate cement (CAC) as a biomaterial has been evaluated for its physical, mechanical and biocompatibility properties. Furthermore, the application of CAC for bone repair is due to its composition and coefficient of thermal expansion, which is similar to that of human bone. Thus, the aim of this study was to evaluate compositions of CAC-based blends as substitutes for bone defects. Five compositions of blends (alumina, zirconia, hydroxyapatite, tricalcium phosphate, chitosan), in addition to the base cement consisting of homogeneous CAC were evaluated as a substitute for bone repair. Additionally, the monotypic biofilm formation was assessed. Creation of a monocortical bone defect was performed on the femurs of rats, which were randomly filled with the different materials. The polymethylmethacrylate (PMMA) group was used as a control. All the animals were euthanized 04 weeks after the surgery procedure. Subsequently, computerized microtomography, histological and histomorphometric analyses were performed to verify the bone repair. To evaluate the formation of biofilms, reference strains of Staphylococcus aureus, Streptococcus mutans and Pseudomonas aeruginosa were cultured on the samples, and the biofilm formed was quantified by the MTT method. In the microtomography and histomorphometry results, it was observed that the blends exhibited better results than the control group, with statistically significant differences (p < 0.05) for alumina and zirconia blends. In the biofilm formation, a statistical difference (p < 0.05) in general was observed between the alumina blends and the control group (p < 0.05). It was concluded that CAC-based blends with alumina and zirconia are promising for use in fillings for bone repair.

铝酸钙水泥（CAC）作为生物材料已经过物理，机械和生物相容性评估。此外，CAC在骨骼修复中的应用是由于其成分和热膨胀系数与人的骨骼相似。因此，本研究的目的是评估基于CAC的共混物的成分，以替代骨缺损。除了由均质CAC组成的基础水泥外，还评估了五种共混物的组成（氧化铝，氧化锆，羟基磷灰石，磷酸三钙，壳聚糖）作为骨修复的替代物。另外，评估了单型生物膜的形成。在大鼠的股骨上进行单皮质骨缺损的产生，这些股骨随机填充有不同的材料。聚甲基丙烯酸甲酯（PMMA）基团用作对照。手术后04周将所有动物安乐死。随后，进行了计算机显微断层扫描，组织学和组织形态分析，以验证骨修复。要评估生物膜的形成，请参考金黄色葡萄球菌，变形链球菌的参考菌株小号和铜绿假单胞菌在样品上培养，并形成生物膜通过MTT法进行定量。在显微断层照相术和组织形态学结果中，观察到该混合物表现出比对照组更好的结果 ，氧化铝和氧化锆混合物具有统计学上的显着差异（p <0.05）。在生物膜形成中， 通常观察到氧化铝混合物与对照组之间的统计学差异（p <0.05）（p  <0.05）。结论是，基于CAC的氧化铝和氧化锆共混物有望用于骨修复填充物中。