Pomegranate ( Punica granatum ) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway.

中文翻译：

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石榴汁和果皮提取物能够抑制前列腺癌细胞系的增殖、迁移和集落形成并调节 Akt/mTOR/S6K 信号通路

众所周知，石榴（Punica granatum）含有多酚，具有许多潜在的健康益处，包括抗肿瘤、抗炎和抗微生物特性。它已被用于治疗癌症的流行药物，癌症仍然是全世界男性癌症相关死亡的主要原因。重要的是，石榴皮是富含多酚的食品工业的宝贵副产品。在这里，我们报告了前列腺癌 DU-145 和 PC-3 细胞系中果汁和果皮水提取物的比较。两种提取物都能够抑制这些细胞的增殖、迁移和集落形成，尽管与果汁相比，果皮提取物具有更强的效果。此外，石榴提取物处理后，生长相关的 mTOR/S6K 信号通路表现出强烈的抑制作用。