Abstract

Loranthus micranthus (LM) is used in the treatment of diabetes and mental disorders in Nigerian folklore medicine. We studied the short-term memory behavior as well as the activity of acetylcholinesterase, antioxidant status and glycolytic flux in cerebrum and cerebellum of diabetic rats treated with LM extract. Histopathological evaluation was used to assess the level of damage on brain tissue due to diabetes complications. Treatment with LM improved short-term memory behavior, significantly reduced the levels of lipid peroxidation (LPO), increased glutathione (GSH) levels and enhanced the activities of antioxidant enzymes. Activities of glucose metabolism enzymes were augmented while acetylcholinesterase (AChE) activity was reduced by LM treatment compared with the untreated diabetic group. Histopathology evaluation revealed the possible influence of LM in reversing diabetes-induced damage in brain tissue. Further studies are required to accentuate the potentials of LM extract in assuaging diabetes-induced neurological deficits.

中文翻译：

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狼尾草对STZ诱导的糖尿病大鼠神经行为缺陷的影响

摘要

桑寄生micranthus（LM）在尼日利亚的民间传说医学中用于治疗糖尿病和精神疾病。我们研究了LM提取物治疗的糖尿病大鼠的短期记忆行为以及乙酰胆碱酯酶的活性，抗氧化剂状态和大脑和小脑中的糖酵解通量。组织病理学评估用于评估糖尿病并发症对脑组织的损害程度。LM治疗改善了短期记忆行为，显着降低了脂质过氧化（LPO）的水平，增加了谷胱甘肽（GSH）的水平，并增强了抗氧化酶的活性。与未治疗的糖尿病组相比，通过LM治疗可增加葡萄糖代谢酶的活性，而降低乙酰胆碱酯酶（AChE）的活性。组织病理学评估揭示了LM在逆转糖尿病引起的脑组织损伤中的可能作用。需要进一步的研究来强调LM提取物缓解糖尿病引起的神经功能缺损的潜力。