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The Basolateral Amygdala in Mechanisms of Stress Resistance in Rats: The Role of Oligopeptides
Neurochemical Journal ( IF 0.5 ) Pub Date : 2019-06-06 , DOI: 10.1134/s1819712419020041
E. V. Koplik , A. A. Bakhmet , L. A. Klyueva , S. V. Klochkova

In order to study the role of the lateral amygdala in the peptidergic mechanisms of stress resistance in rats, we measured the levels of beta-endorphin and substance P in the blood and hypothalamus of stress-resistant and stress-responding rats during emotional stress under conditions of a functional blockade of the basolateral amygdala by anodic polarization. Emotional stress was created by immobilization of rats within narrow chambers, with additional aperiodic electrocutaneous stimulation. It was found that lateral areas of the amygdala play an important role in the maintenance of stress-resistance mechanisms in rats. Their bilateral blockade decreased the resistance to stress. As well, in our experiment we found reciprocal relationships between blood plasma and hypothalamic levels of peptides (substance P and beta-endorphin) both in stress-resistant and stress-responding rats. Thus, peptidergic mechanisms of stress resistance are associated with functioning of the amygdala.

中文翻译:

大鼠应激抗性机制中的基底外侧杏仁核:寡肽的作用

为了研究外侧杏仁核在大鼠应激抵抗的肽能机制中的作用,我们测量了情绪应激条件下应激和应激反应大鼠血液和下丘脑中β-内啡肽和P物质的水平极化对基底外侧杏仁核的功能性阻断作用 通过将大鼠固定在狭窄的室内,再加上非周期性的皮肤电刺激来产生情绪压力。发现杏仁核的外侧区域在维持大鼠的抗压力机制中起重要作用。他们的双边封锁减少了对压力的抵抗力。还有 在我们的实验中,我们发现了抗应激和应激反应大鼠的血浆和下丘脑肽水平(P和β-内啡肽)之间存在相互关系。因此,抗逆性的肽能机制与杏仁核的功能有关。
更新日期:2019-06-06
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