Abstract—We studied the effects of original Russian 3-hydroxypyridine and succinic acid derivatives (emoxypine, reamberin, and mexidol) on the dynamics of activity of monoamine oxidases (МАО-А and МАО-B) and correlated them to the levels of biogenic amines (serotonin and dopamine) in the brain cortex during the first 2 weeks of alloxan-induced diabetes in rats. An injection of 3-hydroxypyridine derivatives for 7 or 14 days (emoxypine and mexidol) to the alloxan-induced diabetic rats at doses that are equivalent to the treatment range in humans prevented an increase in the activity of cortical МАО-А and dopamine deficiency. The strengths of the effects of emoxypine and mexidol were comparable to the effect of the reference agent α‑lipoic acid. The isolated succinic acid derivative (reamberin) attenuated the activity of МАО-А in the neocortex of rats with alloxan-induced diabetes but caused a transient decrease in cortical serotonin and dopamine levels at the early stages of experiments and failed to correct dopamine deficiency by the end of experiments. A course of injection of the studied drugs for 7 and 14 days increased cortical МАО-B activity; this increase was not associated with a parallel shifts in monoamine levels in the brain cortex of rats with alloxan diabetes. The changes in the activity of cortical МАО that were induced by the drugs were not associated with their effect on the level of circulating corticosterone and hyperglycemia in rats with alloxan-induced diabetes.

中文翻译：

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3-羟基吡啶和琥珀酸衍生物对四氧嘧啶糖尿病大鼠脑皮质单胺氧化酶活性的影响

摘要-我们研究了原始的俄罗斯3-羟基吡啶和琥珀酸衍生物（莫西平，reamberin和mexidol）对单胺氧化酶（МАО-А和МАО-B）活性动力学的影响，并将它们与生物胺含量相关联（在四氧嘧啶诱发的大鼠糖尿病的前两周，大脑皮层中的5-羟色胺和多巴胺。以等同于人类治疗范围的剂量向四氧嘧啶诱导的糖尿病大鼠注射7天或14天的3-羟基吡啶衍生物（依莫西平和美西多）可防止皮质МАО-А活性增加和多巴胺缺乏。莫西平和美西多的作用强度与参考剂α-硫辛酸的作用相当。分离出的琥珀酸衍生物（reamberin）减弱了四氧嘧啶诱发的糖尿病大鼠新皮层中МАО-А的活性，但在实验的早期导致皮质5-羟色胺和多巴胺水平的短暂降低，但未能通过多巴胺缺乏症纠正多巴胺缺乏症。实验结束。一个疗程的7到14天注射皮质醇МАО-B活性增加；这种增加与四氧嘧啶糖尿病大鼠大脑皮质中单胺水平的平行变化无关。药物诱导的皮质МАО活性的变化与它们对四氧嘧啶诱发的糖尿病大鼠的循环皮质酮水平和高血糖的影响无关。