Abstract

Fexofenadine hydrochloride is an antihistamine agent used for the treatment of allergic disorders like rhinitis. It is a second generation antihistamine. Montelukast sodium is an anti-asthmatic agent and leukotriene receptor antagonist used in the treatment of respiratory disorders. This article exemplifies the reported analytical methods like electrometric methods, ultraviolet spectroscopy, mass spectroscopy, thin layer chromatography, high performance liquid chromatography, high performance thin layer chromatography and tandem spectroscopy for determination of fexofenadine HCl and montelukast sodium in dosage form and in biological matrices. This review covers almost all the analytical methods for fexofenadine hydrochloride and montelukast sodium form 1968-2018 years. Complete analytical validation parameters reported are discussed in this review for both analytes. Among various analytical methods, HPLC and UV-visible spectrophotometry were found to be the most extensively used methods by the researchers.

摘要

Fexofenadine hydrochloride 是一种抗组胺剂，用于治疗过敏性疾病，如鼻炎。它是第二代抗组胺药。孟鲁司特钠是一种抗哮喘药和白三烯受体拮抗剂，用于治疗呼吸系统疾病。本文举例说明了已报道的分析方法，如电测法、紫外光谱法、质谱法、薄层色谱法、高效液相色谱法、高效薄层色谱法和串联光谱法，用于测定剂型和生物基质中的非索非那定 HCl 和孟鲁司特钠。本综述涵盖了1968-2018年间盐酸非索非那定和孟鲁司特钠晶型的几乎所有分析方法。本综述讨论了两种分析物报告的完整分析验证参数。在各种分析方法中，研究人员发现高效液相色谱法和紫外-可见分光光度法是最广泛使用的方法。