Vitellaria paradoxa (V. paradoxa) is a plant used in traditional medicine in the treatment of many diseases including diabetes mellitus. Although the different parts of this plant are used empirically as antidiabetic drug, no scientific work to our knowledge has yet been undertaken to evaluate its effects on blood glucose, and lipid and antioxidant parameters of diabetic animals. The objective of this study is therefore to evaluate the hypoglycaemic, hypolipidemic and antioxidant activities of the aqueous extract of V. paradoxa barks in diabetic rats. Diabetes was induced by intraperitoneal injection of alloxan (120 mg/kg bw). Thirty male albino rats were divided into groups and orally treated for 14 days with distilled water, glibenclamide (2.5 mg/kg bw) and aqueous extract of V. paradoxa (125, 250 and 500 mg/kg bw). Glycaemia, insulin level, relative body weight, hepatic glycogen level, some liver enzymes, and lipid and antioxidant parameters were evaluated. The results showed that the extract caused a significant increase in relative body weight, insulin level, HDL-cholesterol, hepatic glycogen rate, and fructose-1,6-biphosphate and glucokinase activities. A significant decrease in glycaemia, glucose-6-phosphatase activity, total cholesterol, triglycerides and LDL-cholesterol were also observed after the administration of V. paradoxa. Glutathione level and the activities of catalase and superoxide dismutase increased significantly while the nitric oxide and malondialdehyde levels decreased significantly in the liver of animals treated with the extract of V. paradoxa. These results justify the hypoglycaemic, hypolipidemic and antioxidant effects of aqueous extract of V. paradoxa barks, which can reduce the complications associated with diabetes.

中文翻译：

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Vitroaria paradoxa树皮在四氧嘧啶诱导的糖尿病大鼠中的抗糖尿病和抗氧化潜力

矛盾的Vitellaria paradoxa（V. paradoxa）是一种用于传统医学的植物，可用于治疗包括糖尿病在内的许多疾病。尽管该植物的不同部位在经验上被用作抗糖尿病药，但据我们所知，尚未进行任何科学工作来评估其对糖尿病动物血糖，脂质和抗氧化参数的影响。因此，本研究的目的是评估糖尿病大鼠中V. paradoxa树皮水提取物的降血糖，降血脂和抗氧化活性。腹膜内注射四氧嘧啶（120 mg / kg bw）可诱发糖尿病。将三十只白化病雄性大鼠分为几组，分别用蒸馏水，格列本脲（2.5 mg / kg bw）和悖论弧菌水提取物（125、250和500 mg / kg bw）口服治疗14天。血糖，胰岛素水平，评估相对体重，肝糖原水平，一些肝酶以及脂质和抗氧化剂参数。结果表明，该提取物引起相对体重，胰岛素水平，HDL-胆固醇，肝糖原率以及1,6-二磷酸果糖和葡萄糖激酶活性的显着增加。服用V. paradoxa后，血糖，葡萄糖-6-磷酸酶活性，总胆固醇，甘油三酸酯和LDL-胆固醇也显着下降。用悖论弧菌提取物处理的动物肝脏中的谷胱甘肽水平以及过氧化氢酶和超氧化物歧化酶的活性显着增加，而一氧化氮和丙二醛的水平显着降低。这些结果证明了V的水提取物具有降血糖，降血脂和抗氧化作用。