This work was undertaken to investigate the effect of antigen-conjugated gold nanoparticles on the functional activity of cells of the reticuloendothelial system. Experiments using rat and mouse peritoneal cells assessed the dynamics of the total respiratory activity of macrophages and the activity of mitochondrial dehydrogenases on exposure to colloidal gold conjugates of high- and lowmolecular-weight antigens. Both gold nanoparticles and their antigen conjugates stimulated the respiratory activity of the macrophages and the activity of macrophage mitochondrial enzymes. This stimulation may be an essential factor determining the adjuvant properties of colloidal gold, found by us in prior work.

中文翻译：

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金纳米粒子对腹腔巨噬细胞呼吸活性的影响

开展这项工作是为了研究结合抗原的金纳米颗粒对网状内皮系统细胞功能活性的影响。使用大鼠和小鼠腹膜细胞进行的实验评估了巨噬细胞总呼吸活动的动力学和线粒体脱氢酶在暴露于高分子量和低分子量抗原的胶体金偶联物时的活性。金纳米粒子和它们的抗原结合物都刺激了巨噬细胞的呼吸活性和巨噬细胞线粒体酶的活性。这种刺激可能是我们在之前的工作中发现的决定胶体金佐剂特性的一个重要因素。