To discover and develop novel active molecules, in this study, a series of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties were designed and synthesized. Bioassay results revealed that some of the target compounds possessed good insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), respectively, which were even better than those of the commercial insecticidal agents chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. The results favored our rational design intention and provide a new class of small-molecule inhibitors available for the development of active insecticidal agents targeting P. xylostella, V. aphids, and E. vitis.

中文翻译：

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含有1,3,4-恶二唑和硫醚部分作为活性杀虫剂的新型除虫菊酯衍生物的设计，合成和生物学评估

为了发现和开发新型活性分子，在这项研究中，设计并合成了一系列含有1,3,4-恶二唑和硫醚部分的新型除虫菊酯衍生物。生物测定结果表明，某些目标化合物对小菜蛾（P. xylostella），蔬菜蚜虫（V. aphids）和Empoasca vitis（E. vitis）具有良好的杀虫活性。），甚至比市售杀虫剂毒死rif，β氯氰菊酯，多杀菌素和印za素更佳。结果有利于我们合理的设计意图，并提供了一类新的小分子抑制剂，可用于开发针对小菜蛾，蚜虫和葡萄球菌的活性杀虫剂。