Neuropathic pain is a chronic secondary pain condition, which is a consequence of peripheral or central nervous (somatosensory) system lesions or diseases. It is a devastating condition, which affects around 7% of the general population. Numerous etiological factors contribute to the development of chronic neuropathic pain. It can originate from the peripheral part of the nervous system such as in the case of trigeminal or postherpetic neuralgia, peripheral nerve injury, painful polyneuropathies, or radiculopathies. Central chronic neuropathic pain can develop as a result of spinal cord or brain injury, stroke, or multiple sclerosis. As first-line pharmacological treatment options, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and gabapentinoids are recommended. In trigeminal neuralgia, carbamazepine and oxcarbazepine are the first-choice drugs. In drug-refractory cases, interventional, physical, and psychological therapies are available. This review was structured based on a PubMed search of papers published in the field from 2010 until May 2019.

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周围和中枢神经性疼痛的治疗方法

神经性疼痛是一种慢性继发性疼痛，是周围或中枢神经（躯体感觉）系统病变或疾病的结果。这是一个毁灭性的状况，影响了约7％的总人口。许多病因因素导致慢性神经性疼痛的发展。它可以起源于神经系统的周围部分，例如三叉神经或带状疱疹后遗神经痛，周围神经损伤，疼痛的多发性神经病或神经根病。脊髓或脑损伤，中风或多发性硬化可导致中枢性慢性神经性疼痛。作为一线药理治疗选择，建议使用三环类抗抑郁药，5-羟色胺-去甲肾上腺素再摄取抑制剂和加巴喷丁类药物。在三叉神经痛中 卡马西平和奥卡西平是首选药物。在药物难治性病例中，可以采用介入，物理和心理疗法。这篇评论是根据2010年至2019年5月在该领域发表的论文进行PubMed搜索而构建的。