Abstract

Male hybrid mice (F1 CBA × C57BL/6J) were kept for 1.5 h at 39.5°С. In cognitive tests (extrapolation and puzzle-box elementary logic task solution), mice of the experimental groups (after exposure to an elevated temperature) solved the tasks more quickly and more successfully, while their activity in the “small open field” (in which no stress-inducing stimuli were present) and in the Porsolt test (unescapable swimming) was higher than in control mice. In separate experiments, the temporary impairment in the adult neurogenesis (the decrease of new cell numbers detected immunо-histochemically by the marker Ki67) after elevated temperature exposure was demonstrated in both the subgranular area of dentate fascia and in the subventricular proliferative zone of the forebrain. The heating treatment was accompanied by the increase of HSP-70 expression at the time point 3 h after the treatment, while no differences from control were found after 24 h.

中文翻译：

---

单次加热处理对实验室小鼠行为，成年神经发生和热休克蛋白HSP-70表达的影响

摘要

将雄性杂种小鼠（F1 CBA×C57BL / 6J）在39.5°C放置1.5小时。在认知测试（外推和拼图盒基本逻辑任务解决方案）中，实验组的小鼠（暴露于高温后）更快，更成功地解决了任务，而它们的活动却在“小空旷的领域”（其中没有压力诱导刺激存在），并且在Porsolt测试（无法逃避的游泳）中高于对照组小鼠。在单独的实验中，在齿状筋膜的亚颗粒区和前脑室的脑室下增生区均证实了高温暴露后成人神经发生的暂时性损伤（通过标记Ki67免疫组化检测的新细胞数量减少）。 。