Background: The growing interest in mesenchymal stromal cells (MSCs) in equine medicine, together with the development of MSC biobanking for allogeneic use, raises concerns about biosafety of such products. MSCs derived from umbilical cord (UC) carry an inherent risk of contamination by environmental conditions and vertical transmission of pathogens from broodmares. There is yet no report in the scientific literature about horses being contaminated by infected MSC products, and no consensus about systematic infectious screening of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) to ensure microbiological safety of therapeutic products.

中文翻译：

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通过系统性病原体筛查外周血母血和成对的UC-MSC评估马脐带间充质基质细胞的生物安全性。

背景：马医学对间充质基质细胞（MSCs）的兴趣与日俱增，以及同种异体用途的MSC生物库的发展引起了人们对该产品生物安全性的担忧。源自脐带（UC）的MSC具有环境条件和亲鱼垂直传播病原体的固有风险。科学文献中还没有关于马被感染的MSC产品污染的报道，也没有关于对脐带间充质基质细胞（UC-MSC）进行系统感染性筛选以确保治疗产品的微生物安全性的共识。