Our aim was to study the association between the rubber accelerators and predisposing factors of irritant contact dermatitis (ICD) among the semiconductor factory workers. The research design was a historical cohort study. The study population was divided into two groups: (1) the rubber accelerator exposure group, including workers who wore natural rubber finger cots containing 2,2 dibenzthiazyl disulfide (MBTS), zinc diethyldithiocarbamate (ZDEC), and zinc dibutyldithiocarbamate (ZDBC); and (2) the non-rubber accelerator exposure group, including the workers who wore finger cots with less accelerators and without ZDBC (i.e., the non-exposed group). The samples were calculated, and each group comprised 99 workers. The content of rubber accelerators in the finger cots was determined using high-performance liquid chromatography technique. Cases of ICD and the respective associated factors were collected from the medical records as well as information derived from the questionnaire. Inferential statistics using multiple regression analysis were applied and the results presented as relative risk (RR), adjusted relative risk (adjusted RR), and the 95% confidence interval (CI). The demographics of the exposed and non-exposed group were statistically different in age, duration of employment, duration of contact to rubber accelerators, underlying atopic diseases, underlying allergic rhinitis, family history of atopic diseases, and family history of allergic rhinitis. The results showed that the ICD occurred in 27 (27.3%) of workers in the exposed group compared to 4 (4.0%) of workers in the non-exposed group. The adjusted RR of rubber accelerators containing MBTS, ZDEC, and ZDBC was 9.84 (95% CI 3.70, 26.15) and the predisposing factors which associated with ICD were finger cot contact duration more than 4 years, underlying allergic rhinitis, and family history of atopic diseases [1.78 (95% CI 1.03, 3.08), 1.50 (95% CI 0.85, 2.64) and 1.97 (95% CI 1.12, 3.46), respectively], while having underlying atopic dermatitis was found to be a protective factor adjusted RR 0.62 (95% CI 0.10, 4.13). Rubber accelerators MBTS, ZDEC, and ZDBC were the causes of ICD. The possible agent was ZDBC. Other predisposing factors play less important role in this epidemic.

中文翻译：

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橡胶促进剂引起的刺激性接触性皮炎的罕见爆发：一项历史队列研究

我们的目的是研究半导体工厂工人中橡胶促进剂与刺激性接触性皮炎（ICD）诱发因素之间的关联。研究设计是一项历史队列研究。研究人群分为两组：（1）橡胶促进剂暴露组，包括穿着天然橡胶手指套的工人，其中包含2,2二苯并噻唑二硫化物（MBTS），二乙基二硫代氨基甲酸锌（ZDEC）和二丁基二硫代氨基甲酸锌（ZDBC）；（2）非橡胶促进剂暴露组，包括穿着有较少促进剂且没有ZDBC的手指套的工人（即，非暴露组）。计算了样本，每组包括99名工人。使用高效液相色谱技术测定手指套中橡胶促进剂的含量。从病历以及问卷调查中收集了ICD病例及其相关因素。应用使用多元回归分析的推论统计，结果表示为相对风险（RR），调整后的相对风险（调整后的RR）和95％置信区间（CI）。暴露组和未暴露组的人口统计学差异在年龄，就业时间，接触橡胶促进剂的时间，潜在的特应性疾病，潜在的过敏性鼻炎，特应性疾病的家族病史和过敏性鼻炎的家族史上有统计学差异。结果显示，暴露组的ICD发生在27名工人中（27.3％），而未暴露组的ICD发生在4名工人中（4.0％）。含MBTS，ZDEC和ZDBC的橡胶促进剂的调整后RR为9。84（95％CI 3.70，26.15）和与ICD相关的诱发因素是指婴儿床接触时间超过4年，潜在的过敏性鼻炎和特应性疾病的家族史[1.78（95％CI 1.03，3.08），1.50（分别具有95％CI 0.85、2.64和1.97（95％CI 1.12、3.46）]，同时具有潜在的特应性皮炎是保护因子调整后的RR 0.62（95％CI 0.10、4.13）。橡胶促进剂MBTS，ZDEC和ZDBC是导致ICD的原因。可能的代理是ZDBC。其他易患因素在该流行病中的作用较小。分别]，而潜在的特应性皮炎被发现是保护因子调整后的RR 0.62（95％CI 0.10，4.13）。橡胶促进剂MBTS，ZDEC和ZDBC是导致ICD的原因。可能的代理是ZDBC。其他易患因素在该流行病中的作用较小。分别]，而潜在的特应性皮炎被发现是保护因子调整后的RR 0.62（95％CI 0.10，4.13）。橡胶促进剂MBTS，ZDEC和ZDBC是导致ICD的原因。可能的代理是ZDBC。其他易患因素在该流行病中的作用较小。