Cardiac diseases instigated by the exposure of nanoparticles have gained tremendous attention of research scientists in recent days. After entering the blood stream, nanoparticles have the ability to affect the cardiomyocytes, resulting in the cardiac failure. In this work, the toxicity of biosynthesized gold nanoparticles (AuNPs) on cardiomyocytes of rats was studies. AuNPs were prepared by the reduction of aqueous HAuCl₄ using C. viscosa leaf extract. An optical absorption band for AuNPs was found at 540 nm using UV–visible spectrophotometer. Transmission electron microscopy (TEM) results showed the formation of gold nanocluster with size existing in the range of 1 to 1.5 nm. Also, Fourier transform infrared (FTIR) spectroscopic results confirmed the capping of AuNPs with C. viscosa leaf extract polyphenols. Further, toxicity studies revealed that the levels of gold in the serum and heart, and myocardial enzymes in treated animals were suggestively improved in a concentration-dependent way. Furthermore, treatment with AuNPs resulted the prominent ultrastructural and histological changes in the hearts of treated rats. Additionally, a substantial apoptosis was found in the treated animals. The obtained results indicated that AuNPs has the possibility to enter the circulatory system via lungs, and are circulated to heart resulting the cardiovascular injury. AuNPs-persuaded apoptosis through mitochondrial pathway may play a key role in inducing cardiac failure.

中文翻译：

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气管内滴注大鼠后金纳米簇的生态友好制造及其诱导心肌细胞凋亡。

近年来，由于纳米颗粒的暴露而引发的心脏疾病引起了研究科学家的极大关注。进入血流后，纳米颗粒具有影响心肌细胞的能力，从而导致心力衰竭。在这项工作中，研究了生物合成的金纳米颗粒（AuNPs）对大鼠心肌细胞的毒性。通过使用粘胶梭菌叶提取物还原HAuCl ₄水溶液来制备AuNP 。使用紫外可见分光光度计在540 nm处发现了AuNPs的光吸收带。透射电子显微镜（TEM）结果显示金纳米簇的形成，其大小在1至1.5 nm范围内。此外，傅立叶红外光谱（FTIR）光谱结果证实了AuNPs的封端C.粘胶叶提取物多酚。此外，毒性研究表明，治疗动物中的血清和心脏中的金水平以及心肌酶水平提示浓度依赖性升高。此外，用AuNPs治疗在所治疗的大鼠心脏中引起显着的超微结构和组织学变化。另外，在治疗的动物中发现大量的细胞凋亡。获得的结果表明，AuNPs可能通过肺进入循环系统，并循环到心脏，从而导致心血管损伤。AuNPs通过线粒体途径诱使细胞凋亡可能在诱发心力衰竭中起关键作用。