The metal-organic-frameworks (MOFs) materials are used as drug carrying substrate in the controlled release of drugs. MOFs are also considered to harness dual or multiple modalities in therapeutic and diagnostic applications. Based on the research that took place over the last 10 years, this article presents an overview on the recent development of the unmodified and modified MOFs used in drug controlled release applications, and describes their biological evaluations such as, biocompatibility, bio-toxicity, cellular uptakes, tissue responses, and intracellular drug delivery. This review illustrates enormous diversities and complexities which cover complex designs and syntheses, types of MOFs being used, drug loadings, types of drug used, drug release kinetics, and ranges of biological evaluations on the MOFs. Perspectives, insights, critical reflections, and future outlook are presented on the area of drug controlled release research using MOFs.

中文翻译：

---

金属有机骨架在药物控制释放中的应用

金属有机骨架（MOF）材料在控释药物中用作载药基质。MOF还被认为在治疗和诊断应用中具有双重或多种形式。基于过去十年的研究，本文概述了用于药物控释应用的未修饰和修饰MOFs的最新发展，并描述了它们的生物学评价，例如生物相容性，生物毒性，细胞摄取，组织反应和细胞内药物传递。这篇综述说明了巨大的多样性和复杂性，涵盖了复杂的设计和合成，使用的MOF类型，药物载量，使用的药物类型，药物释放动力学以及对MOF进行生物学评估的范围。观点，见解，