Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

中文翻译：

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血小板 ATP、整合素 αvβ3 上的甲状腺激素受体和癌症转移。

当癌细胞和血小板相互作用时，活化的血小板可能有助于肿瘤细胞的转移行为。这种相互作用需要细胞和血小板表面整合素。甲状腺激素 L-甲状腺素 (T4) 是肿瘤细胞和血小板上整合素 αvβ3 上激素受体的主要配体。T4 激活整合素，促进血小板聚集和脱颗粒（局部 ATP 释放）并刺激肿瘤细胞增殖。通过本文综述的多种分子机制，细胞外 ATP 促进肿瘤细胞侵袭和转移，并支持 T4 作为促转移因子的作用。