Exercise before pregnancy attenuates the effects of prenatal stress in adult mice in a sex-dependent manner,International Journal of Developmental Neuroscience

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Exercise before pregnancy attenuates the effects of prenatal stress in adult mice in a sex-dependent manner
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-04-01 , DOI: 10.1002/jdn.10001
Carolina Luft _{1,

2} , Isadora Perez Levices ₁ , Mariana Severo da Costa ₁ , Gabriela Viegas Haute ₂ , Rodrigo Grassi-Oliveira ₃ , Jarbas Rodrigues de Oliveira ₂ , Márcio Vinícius Fagundes Donadio _{1,

2}

Affiliation

The present study aimed to investigate the long‐term effects of exercise before pregnancy on changes induced by prenatal stress. Female and male Balb/c mice were divided into three groups: control (CON), prenatal restraint stress (PNS), and exercise before the gestational period plus PNS (EX + PNS). As adult, fear/anxiety behavior, corticosterone secretion, expression of hypothalamic‐pituitary‐adrenal (HPA)‐related genes, as well as epigenetic modifications were evaluated. Exercise before gestation did not prevent the increased fear/anxiety behavior in PNS mice. A nearly significant (p = .06) basal corticosterone increase was observed in PNS males and the exercise before pregnancy reduced the stress‐induced corticosterone increase in PNS females. In addition, an increase on prefrontal cortex (PFC) CRHR1 gene expression was observed in PNS females, which was attenuated by the exercise before gestation. We have also found a glucocorticoid receptor (GR) gene expression decrease in the prefrontal cortex in PNS males, as well as a histone H3 acetylation decrease (p = .06) close to the significance level. In conclusion, pregestational exercise may attenuate developmental changes induced by prenatal stress in a sex‐dependent manner.

中文翻译：

孕前运动以性别依赖的方式减弱成年小鼠产前压力的影响

本研究旨在调查孕前运动对产前压力引起的变化的长期影响。雌性和雄性 Balb/c 小鼠分为三组：对照组（CON）、产前束缚应激（PNS）和孕期前运动加 PNS（EX+PNS）。成年后，评估了恐惧/焦虑行为、皮质酮分泌、下丘脑-垂体-肾上腺 (HPA) 相关基因的表达以及表观遗传修饰。妊娠前锻炼并不能阻止 PNS 小鼠增加的恐惧/焦虑行为。在 PNS 男性中观察到几乎显着 (p = .06) 的基础皮质酮增加，并且怀孕前的运动减少了 PNS 女性中压力引起的皮质酮增加。此外，在 PNS 女性中观察到前额叶皮层 (PFC) CRHR1 基因表达增加，这在怀孕前的运动中减弱了。我们还发现 PNS 男性前额叶皮层的糖皮质激素受体 (GR) 基因表达降低，以及接近显着性水平的组蛋白 H3 乙酰化降低 (p = .06)。总之，孕前运动可能以性别依赖的方式减弱由产前压力引起的发育变化。

更新日期：2020-04-01

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