Latimer and Rodebush (J Am Chem Soc 42: 1419–1433, 1920) discussed the ways a Lewis dot structure could be drawn for liquid water and proposed that the H held between two octets constitutes a bond in 1920. When it was realized that the other molecule of life, DNA, owes its double helix structure to specific hydrogen bonds between A–T (two) and C–G (three) base pairs, the interest in hydrogen bonding grew dramatically. While hydrogen bonding could be readily seen in water and DNA, it was not so easy to understand leading to continuous debates about what it means. This article gives a personal perspective of the evolution of hydrogen bonding since the Latimer and Rodebush paper to the recent IUPAC definition of hydrogen bond, published in 2011 and now. Is there a third C–H···O hydrogen bond in the A–T base pair?

中文翻译：

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在 Latimer 和 Rodebush 纸问世一百年后，氢键仍然是一头大象！

Latimer 和 Rodebush (J Am Chem Soc 42: 1419–1433, 1920) 讨论了可以为液态水绘制路易斯点结构的方式，并在 1920 年提出两个八位字节之间的 H 构成了一个键。当人们意识到另一个生命分子 DNA 的双螺旋结构归功于 A-T（两个）和 C-G（三个）碱基对之间的特定氢键，因此对氢键的兴趣急剧增加。虽然在水和 DNA 中可以很容易地看到氢键，但它并不那么容易理解，导致对其含义的持续争论。这篇文章给出了自 Latimer 和 Rodebush 的论文到 2011 年和现在发表的 IUPAC 对氢键的最新定义以来氢键演变的个人观点。A-T 碱基对中是否存在第三个 C-H···O 氢键？