Injectable biomaterials have gained significant attention in recent years since they can be delivered to the defect sites through minimally-invasive approaches. In this work, thermo-responsive injectable hydrogels containing borate-based bioactive glass particles and carbon-based nanopowders were designed for bone tissue engineering applications. For this purpose, mixtures of Pluronic F127 block-copolymer and 13-93B3 bioactive glass particles with different sizes (2.3 µm, 14 µm, 150 µm) were prepared in aqueous medium and their in situ gelation were investigated through rheological measurements as a function of temperature. Effects of graphene nanopowders and multi-walled carbon nanotubes on the flow behavior of the designed hydrogel system were also investigated. Results revealed that viscosity of the prepared hydrogel system was strongly dependent on the temperature and the bioactive glass particle size. Inclusion of graphene and multi-walled carbon nanotubes in this system caused a further increase in viscosity. All of the hydrogel compositions designed in the study showed shear thinning flow behavior which is a crucial parameter for injectability. Drug release studies showed that the addition of bioactive glass and carbon-based nanoparticles improved the drug release behavior of the prepared hydrogels.

中文翻译：

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含生物活性玻璃和碳基纳米粉的可注射Pluronic F-127水凝胶的流动行为和药物释放研究

近年来，由于可注射生物材料可以通过微创方法传递到缺损部位，因此备受关注。在这项工作中，为骨组织工程应用设计了包含硼酸盐基生物活性玻璃颗粒和碳基纳米粉的热响应型可注射水凝胶。为此，在水性介质中制备了Pluronic F127嵌段共聚物和13-93B3生物活性玻璃颗粒的不同尺寸（2.3 µm，14 µm，150 µm）的混合物，并通过流变学方法研究了它们的原位凝胶化性能。温度。还研究了石墨烯纳米粉和多壁碳纳米管对设计水凝胶体系流动行为的影响。结果表明，所制备的水凝胶体系的粘度强烈依赖于温度和生物活性玻璃的粒径。在该体系中包含石墨烯和多壁碳纳米管会导致粘度进一步增加。研究中设计的所有水凝胶组合物均显示出剪切稀化流动行为，这是注射性的关键参数。药物释放研究表明，添加生物活性玻璃和碳基纳米颗粒可改善制备的水凝胶的药物释放行为。研究中设计的所有水凝胶组合物均显示出剪切稀化流动行为，这是注射性的关键参数。药物释放研究表明，添加生物活性玻璃和碳基纳米颗粒可改善制备的水凝胶的药物释放行为。研究中设计的所有水凝胶组合物均显示出剪切稀化流动行为，这是注射性的关键参数。药物释放研究表明，添加生物活性玻璃和碳基纳米颗粒可改善制备的水凝胶的药物释放行为。