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Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows.
Mycotoxin Research ( IF 2.6 ) Pub Date : 2019-12-17 , DOI: 10.1007/s12550-019-00383-7
Janine Saltzmann 1 , Ya Xu 2 , Yun Yun Gong 3 , Johanna Lindahl 4, 5, 6 , Susanne Kersten 1 , Sven Dänicke 1 , Michael N Routledge 2, 7
Affiliation  

The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M1 (AFM1) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM1 and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.

中文翻译:

血液中黄曲霉毒素-牛血清白蛋白加合物与奶牛牛奶中黄曲霉毒素M1关系的初步研究。

黄曲霉毒素(AF)白蛋白加合物通常用作人类黄曲霉毒素暴露的生物标志物。 在肯尼亚进行的黄曲霉毒素缓解研究中,以前使用的用于人类血液中黄曲霉毒素血清白蛋白的ELISA方法用于分析从奶牛收集的牛血清样品(n = 22)。将这些牛的相应牛奶样品中的白蛋白加合物数据与黄曲霉毒素M 1(AFM 1)水平进行比较。对于AFM 1,浓度范围为<LOD至487.9 pg / mL,对于黄曲霉毒素-白蛋白,浓度范围为<LOD和96.3 pg / mg。这项研究表明,黄曲霉毒素-白蛋白加合物可以用作奶牛中长期黄曲霉毒素暴露的量度。
更新日期:2019-12-17
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