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Development of Poor Cell Adhesive Immersion Precipitation Membranes Based on Supramolecular Bis‐Urea Polymers
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2019-12-29 , DOI: 10.1002/mabi.201900277 Ronald C van Gaal 1 , Johnick F van Sprang 1 , Zandrie Borneman 2 , Patricia Y W Dankers 1
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2019-12-29 , DOI: 10.1002/mabi.201900277 Ronald C van Gaal 1 , Johnick F van Sprang 1 , Zandrie Borneman 2 , Patricia Y W Dankers 1
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A variety of biomedical applications requires tailored membranes; fabrication through a mix‐and‐match approach is simple and desired. Polymers based on supramolecular bis‐urea (BU) moieties are capable of modular integration through directed non‐covalent stacking. Here, it is proposed that non‐cell adhesive properties can be introduced in polycaprolactone‐BU‐based membranes by the addition of poly(ethylene glycol) (PEG)‐BU during immersion precipitation membrane fabrication, while unmodified PEG is not retained in the membrane. PEG‐BU addition results in denser membranes with a similar pore size compared to pristine membranes, while PEG addition induces defect formation. Infrared spectroscopy and surface hydrophobicity measurements indicate that PEG‐BU is retained during membrane processing. Additionally, PEG‐BU incorporation successfully leads to poor cell adhesive surfaces. No evidence is observed to indicate PEG retention. The results obtained indicate that the BU system enables intimate mixing of BU‐modified polymers after processing. Collectively, the results provide the first steps toward BU‐based immersion precipitated supramolecular membranes for biomedical applications.
中文翻译：
基于超分子双尿素聚合物的细胞粘附浸没沉淀膜的开发
各种生物医学应用都需要定制的膜。通过混合匹配方法进行制造是简单而理想的。基于超分子双脲（BU）部分的聚合物能够通过定向非共价堆叠进行模块整合。在此建议通过在沉浸沉淀膜制造过程中添加聚乙二醇（PEG）-BU来在聚己内酯-BU基膜中引入非细胞粘合特性，而未改性的PEG不会保留在膜中。与原始膜相比，加入PEG-BU会产生更致密的膜，其孔径与原始膜相似，而加入PEG-BU则会导致缺陷形成。红外光谱和表面疏水性测量表明，PEG-BU在膜处理过程中得以保留。另外，PEG-BU的掺入成功导致不良的细胞粘附表面。没有观察到证据表明PEG保留。获得的结果表明，BU系统可在加工后使BU改性聚合物紧密混合。总的来说，这些结果为生物医学应用中基于BU的浸没沉淀超分子膜的开发提供了第一步。
更新日期：2019-12-29
中文翻译：
基于超分子双尿素聚合物的细胞粘附浸没沉淀膜的开发
各种生物医学应用都需要定制的膜。通过混合匹配方法进行制造是简单而理想的。基于超分子双脲（BU）部分的聚合物能够通过定向非共价堆叠进行模块整合。在此建议通过在沉浸沉淀膜制造过程中添加聚乙二醇（PEG）-BU来在聚己内酯-BU基膜中引入非细胞粘合特性，而未改性的PEG不会保留在膜中。与原始膜相比，加入PEG-BU会产生更致密的膜，其孔径与原始膜相似，而加入PEG-BU则会导致缺陷形成。红外光谱和表面疏水性测量表明，PEG-BU在膜处理过程中得以保留。另外，PEG-BU的掺入成功导致不良的细胞粘附表面。没有观察到证据表明PEG保留。获得的结果表明，BU系统可在加工后使BU改性聚合物紧密混合。总的来说，这些结果为生物医学应用中基于BU的浸没沉淀超分子膜的开发提供了第一步。
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