The accurate delivery of precise amounts of drugs to a specific location can considerably affect various clinical applications. The precise control of drug amount and position is crucial to a successful drug delivery. This paper proposes the use of poly(lactide-co-glycolicacid) (PLGA)-based microspheres to contain precise amounts of drugs and an optical tweezer manipulator to transport these drug-containing microspheres to their targeted sites in vivo . The drugs were delivered by the PLGA-based microspheres to the yolk sac of zebrafish embryos, and a sustained drug release was observed to examine the anti-angiogenesis and angiogenesis activities. The PLGA-based microspheres degraded in zebrafish, thereby verifying that these microspheres can be used as drug carriers in vivo to ensure good biocompatibility and biodegradation. The proposed precise drug delivery approach can be used in protein tests and drug property characterization in vivo .

中文翻译：

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使用基于PLGA的微球和光学操纵器进行精确的药物输送。

将精确量的药物准确地递送到特定位置会大大影响各种临床应用。精确控制药物的数量和位置对于成功递送药物至关重要。本文提出了使用基于聚丙交酯-乙醇酸共聚物（PLGA）的微球来容纳精确量的药物，并使用光学镊子操纵器将这些包含药物的微球运输到目标位置体内 。药物通过基于PLGA的微球传递到斑马鱼胚胎的卵黄囊，并观察到持续释放药物以检查其抗血管生成和血管生成活性。在斑马鱼中降解的基于PLGA的微球，从而验证了这些微球可用作药物载体体内确保良好的生物相容性和生物降解性。提议的精确药物递送方法可用于蛋白质测试和药物特性表征体内 。