BACKGROUND Bone scaffold is one of the most effective methods to treat bone defect. The ideal scaffold of bone tissue should not only provide space for bone tissue growth, but also have sufficient mechanical strength to support the bone defect area. Moreover, the scaffold should provide a customized size or shape for the patient's bone defect. METHODS In this study, strontium-containing Mg-doped wollastonite (Sr-CSM) bioceramic scaffolds with controllable pore size and pore structure were manufactured by direct ink writing 3D printing. Biological properties of Sr-CSM scaffolds were evaluated by apatite formation ability, in vitro proliferation ability of rabbit bone-marrow stem cells (rBMSCs), and alkaline phosphatase (ALP) activity using β-TCP and Mg-doped wollastonite (CSM) scaffolds as control. The compression strength of three scaffold specimens was probed after completely drying them while been submerged in Tris-HCl solution for 0, 2,4 and 6 weeks. RESULTS The mechanical test results showed that strontium-containing Mg-doped wollastonite (Sr-CSM) scaffolds had acceptable initial compression strength (56 MPa) and maintained good mechanical stability during degradation in vitro. Biological experiments showed that Sr-CSM scaffolds had a better apatite formation ability. Cell experiments showed that Sr-CSM scaffold had a higher cell proliferation ability compared with β-TCP and CSM scaffold. The higher ALP activity of Sr-CSM scaffold indicates that it can better stimulate osteoblastic differentiation and bone mineralization. CONCLUSIONS Therefore, Sr-CSM scaffolds not only have acceptable compression strength, but also have higher osteogenesis bioactivity, which can be used in bone tissue engineering scaffolds.

中文翻译：

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含锶对掺镁的硅灰石生物陶瓷支架性能的影响。

背景技术骨支架是治疗骨缺损的最有效方法之一。理想的骨骼组织支架不仅应为骨骼组织的生长提供空间，而且还应具有足够的机械强度以支撑骨骼缺损区域。此外，支架应为患者的骨缺损提供定制的尺寸或形状。方法在本研究中，通过直接墨水书写3D打印来制造具有可控孔径和孔结构的含锶掺Mg硅灰石（Sr-CSM）生物陶瓷支架。通过使用β-TCP和掺镁硅灰石（CSM）支架作为磷灰石形成能力，兔骨髓干细胞（rBMSCs）的体外增殖能力以及碱性磷酸酶（ALP）活性来评估Sr-CSM支架的生物学特性。控制。将三个脚手架样品完全干燥后，将其浸入Tris-HCl溶液中0、2、4和6周，以测试其抗压强度。结果力学测试结果表明，含锶掺Mg硅灰石（Sr-CSM）支架具有可接受的初始抗压强度（56 MPa），并在体外降解过程中保持良好的机械稳定性。生物学实验表明，Sr-CSM支架具有更好的磷灰石形成能力。细胞实验表明，与β-TCP和CSM支架相比，Sr-CSM支架具有更高的细胞增殖能力。Sr-CSM支架的ALP活性较高，表明它可以更好地刺激成骨细胞分化和骨矿化。结论因此，Sr-CSM支架不仅具有可接受的抗压强度，