The emergence and dissemination of high-risk clones of Klebsiella pneumoniae producing extended-spectrum β-lactamases (ESBLs) in animal infections is a critical issue. We report the detection and genomic features of a multidrug-resistant (MDR) ESBL (CTX-M-15)-producing K. pneumoniae infecting a domestic cat. Whole-genome sequencing analysis identified the international ST340 (clonal group CG258), and genes and mutations conferring resistance to β-lactams, aminoglycosides, macrolides, phenicols, fosfomycin, sulfonamides, tetracycline, trimethoprim, and fluoroquinolones. In addition, the presence of genes encoding resistance to disinfectant and heavy metals hazardous to humans was also confirmed. The MDR profile exhibited by the strain contributed to treatment failure and death of the companion animal. Therefore, active surveillance of critical priority lineages of K. pneumoniae should not only focus on human infections but also on veterinary infections.

中文翻译：

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伴侣动物中产生CTX-M-15的肺炎克雷伯菌ST340 / CG258高风险克隆的检测和全基因组分析。

在动物感染中产生高光谱β-内酰胺酶（ESBLs）的肺炎克雷伯氏菌高风险克隆的出现和传播是一个关键问题。我们报告了多药耐药（MDR）ESBL（CTX-M-15）产生肺炎克雷伯菌的检测和基因组特征。感染家猫。全基因组测序分析确定了国际ST340（克隆组CG258），并赋予了对β-内酰胺，氨基糖苷类，大环内酯类，苯酚，磷霉素，磺酰胺类，四环素，甲氧苄啶和氟喹诺酮类耐药的基因和突变。此外，还证实存在编码对消毒剂和对人类有害的重金属的抗性的基因。菌株表现出的MDR谱图导致治疗失败和伴侣动物死亡。因此，对肺炎克雷伯菌关键优先谱系的积极监测不仅应关注人类感染，还应关注兽医感染。