Abstract

The derivatives of 1-aminocyclopropanecarboxylic acid (ACC) over recent decades have attracted close attention from synthetic chemists owing to their high physiological activity as plant growth regulators, conformationally rigid analogs of natural amino acids, and peptidomimetics. The present review considers contemporary approaches to the methods of preparation of amino acids of the ACC series, namely, the alkylation of glycine equivalents with 1,2-electrophiles, the intramolecular cyclization of γ-substituted amino acid derivatives, alkene cyclopropanation under the action of diazo compounds, ylides, and carbene intermediates, as well as other synthetic approaches.

中文翻译：

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1-氨基环丙烷羧酸的制备方法

摘要

1-氨基环丙烷羧酸（ACC）的衍生物在近几十年中由于其作为植物生长调节剂，天然氨基酸的构象刚性类似物和拟肽的高生理活性而受到合成化学家的密切关注。本文综述了ACC系列氨基酸制备方法的当代方法，即用1,2-亲电子试剂对甘氨酸当量进行烷基化，γ-取代的氨基酸衍生物的分子内环化，烯烃环丙烷化作用等。重氮化合物，叶立德和卡宾中间体，以及其他合成方法。