Embraced as a breaking through methodological framework, the exposome is accompanied by novel exposure assessment methods and data processing tools or models. However, systematic mapping of the landscape of exposome studies, including their characteristics, components, tools and language has not been done so far. We conducted a scoping review to answer the question: “Which main domains of the human exposome have been included in the literature and which metrics of exposure(s)/outcome(s) have been used?” We performed a comprehensive search of human studies containing the word “exposom*” and published up to March 8, 2019. We screened 1133 records and 82 studies were included in the analysis. Most studies took place in Europe. Data analysis showed the non-systematic use of the exposome term. Most studies had a longitudinal design (n = 30, 37%), were conducted on adults (n = 40, 51%), and had a clearly defined health outcome in methodology (n = 48, 61%). Omics tools, such as metabolomics were used in 38 studies (49%), while environment-wide association analysis was used in 9 studies (11%). Thirty-seven (48%) studies included all three exposome domains (general external, specific external and internal) while 33 (42%) studies included two. Despite the large number of environmental components that comprise each of the exposome domains, only a subset has been currently studied. An optimized consideration of the components from all exposome domains, as well as the standardization of the exposure and outcome assessment methods is warranted to advance the utility of the human exposome concept.

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人类暴露研究特征的范围界定

该暴露体被视为突破性的方法框架，并伴随着新颖的暴露评估方法和数据处理工具或模型。但是，到目前为止，尚未完成对接触研究领域的系统映射，包括其特征，组成，工具和语言。我们进行了范围界定审查，以回答以下问题：“文献中包括了人类暴露小体的哪些主要领域，以及使用了哪些暴露/结果指标？” 我们对包含“ exposom *”一词的人体研究进行了全面搜索，并出版至2019年3月8日。我们筛选了1133条记录，分析中包括82项研究。大多数研究是在欧洲进行的。数据分析表明暴露术语是非系统性的。大多数研究采用纵向设计（ 在成人中进行了n = 30，37％）（n  = 40，51％），并且在方法学上有明确定义的健康结果（n  = 48，61％）。代谢组学等组学工具已用于38个研究中（49％），而全环境关联分析已用于9个研究中（11％）。三十七（48％）个研究包括所有三个暴露区域（一般外部，特定外部和内部），而33（42％）研究包括两个。尽管构成每个暴露域的环境成分很多，但目前仅研究了一个子集。有必要对来自所有暴露域的成分进行优化考虑，以及暴露和结果评估方法的标准化，以促进人类暴露概念的实用性。