Comparing prognostic values of the 7th and 8th editions of the American Joint Committee on Cancer TNM staging system for gastric cancer,The International Journal of Biological Markers

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Comparing prognostic values of the 7th and 8th editions of the American Joint Committee on Cancer TNM staging system for gastric cancer
The International Journal of Biological Markers ( IF 2.3 ) Pub Date : 2019-12-16 , DOI: 10.1177/1724600819891585
Ming-Hua Zhu ₁ , Ke-Cheng Zhang ₁ , Ze-Long Yang ₁ , Zhi Qiao ₁ , Lin Chen ₁

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In Asian countries, the incidence and mortality of gastric cancer are the highest among malignant tumors.^{1, 2} Accurate and uniform staging helps physicians make informed medical decisions to determine patients’ prognoses and to assess treatment outcomes.^{3, 4} The gastric cancer staging system most widely used worldwide is the Union for International Cancer Control (UICC)/American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM), which is based on tumor infiltration depth (pT), number of lymph node metastases (pN), and the presence of distant metastasis (pM). The 8th edition of TNM staging system (hereafter referred to as the “8th edition”) of gastric cancer was revised as follows: pN3 in the 7th edition was further divided into pN3a and pN3b, and the subgroup staging was adjusted. This revision is based on data from the International Gastric Cancer Association (IGCA), and the patients were mainly from Japan and South Korea (84.8%).^{5, 6} In contrast, the Chinese population with gastric cancer represented a relatively low percentage. People living in China have a high incidence of gastric cancer.^{7, 8} Therefore, it is necessary to verify the applicability of the 8th edition to patients with gastric cancer in China. The present study was designed to investigate whether the 8th edition is better than the 7th edition of the TNM staging system (hereafter referred to as the “7th edition”) for managing Chinese citizens with gastric cancer.

更新日期：2020-04-14

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