The fertilized egg undergoes several cleavage divisions to form the blastocyst in the oviduct. The blastocyst then is transferred to the uterus to initiate implantation, and trophectoderm-derived cells interact with the maternal uterus. The dialogue between mother and embryo is prerequisite for the following embryonic development because a disturbance of this process mainly account for 60% pregnancy loss in human early post-implantation (Emiliani et al., 2005). After implantation, the embryo initiates the milestone event—gastrulation—during which multipotent epiblast cells (EPI) undergo an orchestrated process of morphogenetic cellular movement and differentiation. Through gastrulation, three germ layers (ectoderm, mesoderm, and endoderm) are specified to establish the body plan. Because the embryo is engulfed by maternal tissues and inaccessible, the direct observations and manipulations are obstructed. Currently, the knowledge on human early post-implantation development remains largely unknown.

中文翻译：

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评论“早期原肠胚形成后食蟹猴胚胎的体外培养”。

受精卵经过多次卵裂分裂，在输卵管中形成囊胚。然后将囊胚转移到子宫以开始着床，滋养外胚层衍生的细胞与母体子宫相互作用。母亲和胚胎之间的对话是随后胚胎发育的先决条件，因为这一过程的干扰主要占人类植入后早期妊娠丢失的 60% (Emiliani et al., 2005)。植入后，胚胎启动里程碑事件 — 原肠胚形成 — 在此期间，多能外胚层细胞 (EPI) 经历精心设计的形态发生细胞运动和分化过程。通过原肠胚形成，指定三个胚层（外胚层、中胚层和内胚层）以建立身体计划。因为胚胎被母体组织吞没，无法接近，直接观察和操作受到阻碍。目前，关于人类早期植入后发育的知识在很大程度上仍然未知。