Antimicrobial peptides (AMPs), also known as host defense peptides, are small and mostly polycationic molecules that form part of the innate immune response. There are currently more than 3000 experimentally reported AMPs. Particularly in frogs, the temporin family has been discovered as potential AMPs. The aim of this work is to review the latest publications about this class of peptides, discuss their properties, and present an update of the last studies and new discoveries in the field. More than 130 temporins have been identified in this family. The most studied temporins are temporin A (TA), temporin B (TB), and temporin L (TL). These peptides showed antimicrobial activity against gram-negative, gram-positive bacteria and fungi. Since the discovery of temporins in 1996, several groups of researchers isolated different peptides from various species of frogs that were included as members of this family. Although antimicrobial activity of many temporins has not been analyzed yet, most of them showed antimicrobial and antifungal activities. A combination of nanotechnology and AMPs for temporins in different antimicrobial treatments could be a promising alternative for resistant pathogens. These studies demonstrate that, even with the advancement in scientific research on the composition and antimicrobial activity of temporins, further studies are necessary to wholly understand their components and mechanisms of action.

中文翻译：

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Temporins：潜在药物候选者的方法

抗菌肽（AMP），也称为宿主防御肽，是很小的，大部分是聚阳离子分子，形成先天免疫应答的一部分。当前有超过3000个实验报告的AMP。特别是在青蛙中，temporin家族已被发现是潜在的AMP。这项工作的目的是审查有关此类肽的最新出版物，讨论其性质，并提供该领域最新研究和新发现的更新。在这个家族中已经鉴定出130多种temporins。研究最多的temporin是temporin A（TA），temporin B（TB）和temporin L（TL）。这些肽对革兰氏阴性，革兰氏阳性细菌和真菌具有抗菌活性。自从1996年发现temporins以来，几组研究人员从不同种类的青蛙中分离出不同的多肽，这些青蛙被归为该家族的成员。尽管尚未分析许多temporins的抗菌活性，但大多数都显示出抗菌和抗真菌活性。纳米技术和AMPs在不同的抗菌治疗中的结合可能是抗药性病原体的有前途的替代方法。这些研究表明，即使在关于temporins的组成和抗菌活性的科学研究方面取得了进步，也有必要进行进一步的研究以完全了解它们的组成和作用机理。纳米技术和AMPs在不同的抗菌治疗中的结合可能是抗药性病原体的有前途的替代方法。这些研究表明，即使在关于temporins的组成和抗菌活性的科学研究方面取得了进步，也有必要进行进一步的研究以完全了解它们的组成和作用机理。纳米技术和AMPs在不同的抗菌治疗中的结合可能是抗药性病原体的有前途的替代方法。这些研究表明，即使在关于temporins的组成和抗菌活性的科学研究方面取得了进步，也有必要进行进一步的研究以完全了解它们的组成和作用机理。