Abstract

It has been shown that factor X activity determined in normal plasma using Aspergillus ochraceus protease is comparable with the activity determined with a commercial analogue, a protease from Russell’s viper venom (RVV-X^®). It was revealed that the protease of A. ochraceus, along with the RVV-X^® preparation, can be used to determine the content of factor X in the plasma with its reduced content. A study of the protease activity of A. ochraceus as an activator to factor X showed that it is slightly higher compared to the snake venom preparation, which can make A. ochraceus protease a promising substitute for the snake activator in diagnostics for determining the content of factor X.

中文翻译：

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应用Application曲霉菌胞外蛋白酶测定人血浆中X因子含量的可能性

摘要

它已经显示，因子X的活性在正常血浆使用确定赭曲霉蛋白酶是与用商业类似物，从蝰蛇毒（RVV-X蛋白酶确定的活性可比^®）。据透露，的蛋白酶A.赭，用RVV-X沿^®制剂，可以被用来确定第X因子的血浆中，其含量减少的内容。对曲霉作为X因子激活剂的蛋白酶活性的研究表明，与蛇毒制剂相比，it曲霉的蛋白酶活性稍高，这可以使曲霉蛋白酶在确定含量的诊断中成为蛇激活剂的有希望的替代品。 X因子。