Abstract

Objective

To investigate the association between pain and perfusion in bone marrow lesions with and without cysts assessed dynamic contrast-enhanced (DCE)-MRI in patients with knee osteoarthritis.

Subjects and methods

In a cross-sectional setting, perfusion in bone marrow lesions was assessed using 3 Tesla MRI and correlated (Spearman’s rank correlation) to pain using the knee injury and osteoarthritis outcome score (KOOS). Bone marrow lesions were assessed across the whole knee with DCE-MRI using heuristic variable and non-contrast-enhanced-MRI using MRI osteoarthritis knee score.

Results

Data were available from 107 participants. The participants had a mean age of 60.8 years, mean BMI of 34.5 kg/m², mean KOOS-pain of 63.7 (0–100 scale), and mean bone marrow lesion sum score of 6.5 (0–45 scale). The bivariate association between KOOS-pain and the heuristic perfusion variable time to peak in bone marrow lesions containing subchondral cysts showed a statistically significant correlation (r = 0.40; p = 0.002). The perfusion variables were not correlated with KOOS-pain in bone marrow lesions without cysts.

Conclusion

In this cross-sectional study, the rate of perfusion (TTP) in bone marrow lesions containing subchondral cysts was associated with pain in patients with knee OA. DCE-MRI has a potential to be used for separating subtypes of OA.

中文翻译：

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DCE-MRI评估的骨髓损伤灌注及其与膝骨关节炎疼痛的关系：一项横断面研究

摘要

目的

为了研究疼痛与有无囊肿的骨髓病变的灌注之间的关系，评估了膝骨关节炎患者的动态对比增强（DCE）-MRI。

主题与方法

在横断面中，使用3 Tesla MRI评估骨髓病变的灌注，并使用膝关节损伤和骨关节炎预后评分（KOOS）将疼痛与疼痛相关（Spearman等级相关）。使用启发式变量通过DCE-MRI评估整个膝关节的骨髓病变，使用MRI骨关节炎膝关节评分评估非对比增强MRI。

结果

数据来自107位参与者。参与者的平均年龄为60.8岁，平均BMI为34.5 kg / m ²，平均KOOS疼痛为63.7（0–100量表），平均骨髓病变总评分为6.5（0–45量表）。在包含软骨下囊肿的骨髓病变中，KOOS疼痛与启发式灌注可变峰时间之间的双变量关联显示出统计学显着的相关性（r = 0.40；p = 0.002）。在没有囊肿的骨髓病变中，灌注变量与KOOS疼痛无关。

结论

在这项横断面研究中，膝骨关节炎患者的含有软骨下囊肿的骨髓病变中的灌注率（TTP）与疼痛相关。DCE-MRI有潜力用于分离OA的亚型。