Abstract

This paper discusses the mechanical properties of chitosan-based film matrices, as well as optimization of these properties by adding chitin nanofibrils. It has been shown that the filler addition stabilizes the mechanical properties of the composite material. By changing the concentration of chitin nanofibrils, it is possible to obtain matrices with different bioactive properties for cultured human dermal fibroblasts. The optimal balance of mechanical properties and bioactivity in relation to the culture of human dermal fibroblasts is possessed by film matrices based on chitosan nanocomposite with the addition of 5% chitin nanofibrils. Film matrices based on chitosan nanocomposite with the addition of 5% chitin nanofibrils provide the optimal balance of mechanical properties and bioactivity for cultured human dermal fibroblasts.

中文翻译：

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基于壳聚糖和几丁质纳米纤维的组织工程复合材料力学性能和生物活性的优化

摘要

本文讨论了基于壳聚糖的薄膜基质的机械性能，以及通过添加几丁质纳米原纤维来优化这些性能。已经表明，填料的添加稳定了复合材料的机械性能。通过改变几丁质纳米原纤维的浓度，有可能获得具有不同生物活性特性的基质，用于培养人真皮成纤维细胞。与人皮肤成纤维细胞的培养相关的机械性能和生物活性的最佳平衡是基于壳聚糖纳米复合材料的薄膜基质（添加5％几丁质纳米纤维）所具有的。基于壳聚糖纳米复合材料并添加5％几丁质纳米纤维的薄膜基质为培养的人类真皮成纤维细胞提供了机械性能和生物活性之间的最佳平衡。