The Bombyx mori nucleopolyhedrovirus (BmNPV) La is a variant BmNPV strain isolated in Laos. La has different features from BmNPV type strain T3 in virulence, production of the polyhedrin protein, and the formation of multicapsid occlusion-derived viruses. Here, the whole-genome sequence of La was compared to the sequences of nine BmNPV and two Bombyx mandarina nucleopolyhedrovirus strains. The complete La genome consisted of 127,618 base pairs with a G + C content of 40.3% and contained putative 136 open reading frames encoding more than 60 amino acids. The La genome lacked the bro-b gene and had the highest identity with that of the T3 strain. A comparison of the transcriptomes of La- and T3-infected cells showed that the expression levels of the polyhedrin and cathepsin genes were greater in cells infected with La as compared to those infected with T3. Interestingly, the virus genes with different RNA levels between the two BmNPV strains were assembled into five clusters in the genome of La. Also, the RNA levels of host ribosomal protein genes were significantly decreased in cells infected with La as compared to those infected with T3.

家蚕核多角体病毒（BmNPV）La是在老挝分离的BmNPV变异株。La在毒力，多面体蛋白的产生以及多衣壳闭塞衍生病毒的形成方面与BmNPV型毒株T3具有不同的特征。在这里，La的全基因组序列与9个BmNPV和2个Bombyx mandarina核多角体病毒株的序列进行了比较。完整的La基因组由127,618个碱基对组成，G + C含量为40.3％，并包含推定的136个开放阅读框，编码超过60个氨基酸。La基因组缺乏bro-b基因，与T3菌株具有最高的同一性。La和T3感染细胞的转录组的比较表明多面体和组织蛋白酶的表达水平与感染T3的细胞相比，感染La的细胞中的基因更大。有趣的是，在两个BmNPV株之间具有不同RNA水平的病毒基因在La基因组中被组装成五个簇。此外，与T3感染的细胞相比，La感染的细胞中宿主核糖体蛋白基因的RNA水平显着降低。 。