Degenerative retinal disease is the major cause of sight loss in the developed world and currently there is a lack of effective treatments. As the loss of vision is directly the result of the loss of retinal cells, effective cell replacement through stem-cell-based therapies may have the potential to treat a great number of retinal diseases whatever their underlying etiology. The eye is an ideal organ to develop cell therapies as it is immune privileged, and modern surgical techniques enable precise delivery of cells to the retina. Furthermore, a range of noninvasive diagnostic tests and high-resolution imaging techniques facilitate the evaluation of any therapeutic intervention. In this review, we evaluate the progress to date of current cell therapy strategies for retinal repair, focusing on transplantation of pluripotent stem-cell-derived retinal pigment epithelium (RPE) and photoreceptor cells.

中文翻译：

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开发用于视网膜变性的干细胞疗法。

退行性视网膜疾病是发达国家视力丧失的主要原因，目前缺乏有效的治疗方法。由于视力丧失直接是视网膜细胞损失的结果，因此通过基于干细胞的疗法进行有效的细胞替代可能有可能治疗大量视网膜疾病，无论其潜在病因如何。眼睛是开发细胞疗法的理想器官，因为它具有免疫特权，现代手术技术可以将细胞精确地输送到视网膜。此外，一系列无创诊断测试和高分辨率成像技术有助于评估任何治疗干预。在这篇综述中，我们评估了目前用于视网膜修复的细胞治疗策略的进展，