In the recent times, many people around the world are suffering drug resistant in most of the antibiotics used in different circumferences. In order to overcome the antibiotic resistance problem, there is need to use of existing antibiotics consciously and prepare novel compounds which exhibit high therapeutic profile against different pathogens with least resistance. In this review we discussed the thiadiazole derivatives and their different biological activities such as anti-inflammatory, anti-helicobacter pylori, anti-microbial, anti-cancer, antiviral, anti-depressant, analgesic, herbicidal and adenosine A3 receptor inhibitor, besides that this review also provides a detailed information about structural activity relationship (SAR) of such a compounds prepared by different medicinal chemist to date. In general, SAR is the smartest tool among the medicinal chemist to create a better therapeutic efficacy and high safety bioactive molecule in a short span of time. Besides that, we pointed out here different challenges of thiadiazole derivatives and its feature perspectives.

中文翻译：

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噻二唑及其衍生物的发生，作用机理，结构活性关系和各种药理活性

近年来，世界各地的许多人在不同领域使用的大多数抗生素都对药物产生抗药性。为了克服抗生素抗性问题，需要有意识地使用现有的抗生素并制备显示出对不同病原体具有最低耐药性的高治疗谱的新型化合物。在这篇综述中，我们讨论了噻二唑衍生物及其不同的生物学活性，例如消炎药，抗幽门螺杆菌，抗微生物药，抗癌药，抗病毒药，抗抑郁药，止痛药，除草剂和腺苷A3受体抑制剂。综述还提供了迄今为止由不同的药物化学家制备的这种化合物的结构活性关系（SAR）的详细信息。一般来说，SAR是药物化学家中最聪明的工具，可以在短时间内创建更好的治疗效果和高安全性的生物活性分子。除此之外，我们在这里指出了噻二唑衍生物的不同挑战及其特征观点。